The 49ers take their high-powered offense south of the border to square off with their NFC West division-rival Cardinals. San Francisco is a sizable favorite and should handle their business. Thus, they’re the more well-represented club. However, gamers will need to fade some of San Francisco’s talented skill-position players and use at least one player from the Cardinals. The following analysis will help whittle the player pool to a manageable size.

Game: San Francisco 49ers at Arizona Cardinals

Spread: SF -10.0 Points

Over/Under: 43.0 Points

49ers Analysis: The 49ers are a run-first team. It's in their DNA. According to numberFire, in the last two games, with Christian McCaffrey up to speed, they ran 49 times with non-quarterbacks and passed 47 times in neutral game scripts.