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NFL DFS GPP Picks & Lineup Advice: Week 1 (2026)

NFL DFS GPP Picks & Lineup Advice: Week 1 (2026)

The players below are the ones I’m looking at for NFL DFS GPP considerations this week. Salaries marked with an * indicate a strong value in pricing difference on FanDuel.

FantasyPros DFS Lineup Optimizer

NFL DFS GPP Main Slate Lineup Advice: Week 1

Quarterbacks

Lamar Jackson (QB – BAL) @ IND | DraftKings: $6,800/FanDuel: 8,400

A healthy Lamar Jackson always has overall QB1 upside. The Colts are not a defensive layup, but a strong defense doesn’t limit Jackson’s upside. Before his injury last season, Jackson opened the season against Buffalo, Cleveland, and Detroit with a minimum of 25 fantasy points in each game, finishing as a top five quarterback each time. The addition of Ja’Kobi Lane gives Jackson more depth at receiver and a new primary deep threat. Week 1 profiles as another ceiling game.

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