Drake Maye Week 5 Outlook - Patriots at Bills

By Ellis Johnson (FantasyPros), Tue, Sep 30th 2025, 3:46pm EDT

The second-year QB is currently the QB4 on the season and has become a mainstay in fantasy leagues. After dominating a previously tough Panthers defense, Maye looks to ride this momentum in a divisional duel against the Bills this week. Statistically, the Bills are a far inferior defense to the Panthers against fantasy QBs. However, we also know that the Bills are dominant in divisional games. Despite allowing the 10th most fantasy points to the position, it wouldn't be surprising if the Bills find a way to limit Maye's production. However, Maye remains a must-start in all fantasy formats, thanks to his rushing ability. On paper, this is a smash start for fantasy purposes.