| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 42.9 | 7.3 | 27.8 | 33.9 | 28 | 111.9 | |||||||||||||
| 2 | Austin Ekeler | RB | WAS | 39.4 | 23.3 | 15.1 | 29.2 | 26.8 | 107 | |||||||||||||
| 3 | Dalvin Cook | RB | FA | 26 | 28.1 | 24.3 | 19 | 24.4 | 97.4 | |||||||||||||
| 4 | Nick Chubb | RB | HOU | 11.5 | 19.8 | 17.1 | 39.3 | 21.9 | 87.7 | |||||||||||||
| 5 | Alvin Kamara | RB | NO | 23.9 | 7 | 37.1 | 11.9 | 20 | 79.9 | |||||||||||||
| 6 | Mark Ingram II | RB | FA | 22.7 | 9.7 | 35.5 | 8.1 | 19 | 76 | |||||||||||||
| 7 | David Johnson | RB | FA | 25.7 | 8.4 | 18.5 | 21.9 | 18.6 | 74.5 | |||||||||||||
| 8 | Derrick Henry | RB | BAL | 28.9 | 17.4 | 11.6 | 11.8 | 17.4 | 69.7 |