| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 10.7 | 47.7 | 19.4 | 25.7 | 31 | 35.6 | 16.4 | 6.8 | - | 24.2 | 193.3 | |||||||||
| 2 | Jonathan Taylor | RB | IND | 17.6 | 6.3 | 8.2 | 20.4 | 31.9 | 28.8 | 18 | 21.2 | 34 | 20.7 | 186.4 | |||||||||
| 3 | Austin Ekeler | RB | WAS | 11.7 | 22.5 | 22.7 | 29.5 | 32.9 | 9.5 | - | 24.4 | 11.2 | 20.6 | 164.4 | |||||||||
| 4 | Najee Harris | RB | LAC | 5.9 | 19.1 | 28.2 | 21.1 | 22.2 | 24.7 | BYE | 21 | 16.8 | 19.9 | 159 | |||||||||
| 4 | Joe Mixon | RB | HOU | 25 | 8.1 | 10.4 | 13.7 | 10.5 | 26.3 | 11.9 | 25.1 | 28 | 17.7 | 159 | |||||||||
| 6 | Alvin Kamara | RB | NO | 18.1 | 7 | 20.8 | 12 | 29.2 | BYE | 33.9 | 16.6 | 20.4 | 19.8 | 158 | |||||||||
| 7 | Cordarrelle Patterson | RB | FA | 8.7 | 23.9 | 16.2 | 34.6 | 18.4 | - | 14.1 | 18.2 | 19.6 | 19.2 | 153.7 | |||||||||
| 8 | Aaron Jones Sr. | RB | MIN | 4.2 | 41.5 | 17.6 | 10.9 | 14.9 | 21 | 8.9 | 24 | 5.3 | 16.5 | 148.3 |