| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 32.9 | 5.3 | 24.8 | 23.9 | 41.7 | 17.7 | - | 23.5 | 34.6 | 20.1 | 24.9 | 224.5 | |||||||
| 2 | Dalvin Cook | RB | FA | 24 | 25.1 | 20.3 | 13 | 19.8 | 11.4 | 26.9 | 23.1 | 11.6 | 24.3 | 20 | 199.5 | |||||||
| 3 | Aaron Jones Sr. | RB | MIN | 3.9 | 21 | 14.3 | 11.8 | 42.2 | 4 | 14.3 | 34.6 | 2.9 | 27.3 | 17.6 | 176.3 | |||||||
| 4 | Derrick Henry | RB | BAL | 27.9 | 15.4 | 10.6 | 10.8 | 13.8 | 3.3 | 16.8 | 6.3 | 21.9 | 31.1 | 15.8 | 157.9 | |||||||
| 5 | Austin Ekeler | RB | WAS | 33.4 | 17.3 | 8.1 | 24.2 | 7.3 | 2.8 | 18.5 | 8.2 | 9.3 | 10.8 | 14 | 139.9 | |||||||
| 6 | Nick Chubb | RB | HOU | 8.5 | 15.8 | 13.1 | 36.3 | 9.9 | 23.9 | - | 9.8 | 9.1 | 12.1 | 15.4 | 138.5 | |||||||
| 7 | Josh Jacobs | RB | GB | 23.3 | 9.9 | 4.4 | 10.8 | 26.3 | - | 13.4 | 8.1 | 24 | 16.1 | 15.1 | 136.3 | |||||||
| 8 | Chris Carson | RB | FA | 18 | 6.7 | 3 | 14.5 | 18.3 | 21.9 | 7.4 | 15 | 11.3 | 16.1 | 13.2 | 132.2 |