| Week 1 | Detroit Lions vs. Kansas City Chiefs | Thursday, September 7th, 2023 at 8:20pm ET |
| Week 2 | Seattle Seahawks vs. Detroit Lions | Sunday, September 17th, 2023 at 1:00pm ET |
| Week 3 | Atlanta Falcons vs. Detroit Lions | Sunday, September 24th, 2023 at 1:00pm ET |
| Week 4 | Detroit Lions vs. Green Bay Packers | Thursday, September 28th, 2023 at 8:15pm ET |
| Week 5 | Carolina Panthers vs. Detroit Lions | Sunday, October 8th, 2023 at 1:00pm ET |
| Week 6 | Detroit Lions vs. Tampa Bay Buccaneers | Sunday, October 15th, 2023 at 4:25pm ET |
| Week 7 | Detroit Lions vs. Baltimore Ravens | Sunday, October 22nd, 2023 at 1:00pm ET |
| Week 8 | Las Vegas Raiders vs. Detroit Lions | Monday, October 30th, 2023 at 8:15pm ET |
| Week 9 | Bye Week | |
| Week 10 | Detroit Lions vs. Los Angeles Chargers | Sunday, November 12th, 2023 at 4:05pm ET |
| Week 11 | Chicago Bears vs. Detroit Lions | Sunday, November 19th, 2023 at 1:00pm ET |
| Week 12 | Green Bay Packers vs. Detroit Lions | Thursday, November 23rd, 2023 at 12:30pm ET |
| Week 13 | Detroit Lions vs. New Orleans Saints | Sunday, December 3rd, 2023 at 1:00pm ET |
| Week 14 | Detroit Lions vs. Chicago Bears | Sunday, December 10th, 2023 at 1:00pm ET |
| Week 15 | Denver Broncos vs. Detroit Lions | Saturday, December 16th, 2023 at 8:15pm ET |
| Week 16 | Detroit Lions vs. Minnesota Vikings | Sunday, December 24th, 2023 at 1:00pm ET |
| Week 17 | Detroit Lions vs. Dallas Cowboys | Saturday, December 30th, 2023 at 8:15pm ET |
| Week 18 | Minnesota Vikings vs. Detroit Lions | Sunday, January 7th, 2024 at 1:00pm ET |
