Another weekend of NFL football has arrived! Unfortunately, the injury watch for fantasy football managers is also here, and that’s certainly the case for Christian McCaffrey. Players who appear on the injury report and haven’t practiced much during the week can often lead to trepidation for managers trying to make fantasy football lineup decisions and/or waiver claims. Don’t fret, though – FantasyPros is here to provide you with all of the latest news and updates on the players who are questionable heading into this week. So, is Christian McCaffrey playing in Week 1? Here’s what we know about Christian McCaffrey‘s injury and his status for Week 1. And use our Are They Playing tool to see the probability of any injured player playing this week, including Christian McCaffrey. So, is Christian McCaffrey playing Week 1?
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Fantasy Football Outlook: Will Christian McCaffrey Play Week 1?
#49ers RB Christian McCaffrey is questionable with a calf injury, but signs are pointing to him playing vs the #Seahawks, per The Insiders.
McCaffrey was running around on the side during practice Friday and was optimistic to reporters. Barring a setback, it’s likely he’ll go. pic.twitter.com/uAkpji5O47
— Ian Rapoport (@RapSheet) September 6, 2025
Christian McCaffrey (calf) questionable to play Sunday
Christian McCaffrey (calf) is officially questionable to play in Sunday’s game against the Seattle Seahawks.
Fantasy Impact
McCaffrey was a surprise addition to the injury report on Thursday and was not able to practice on Friday due to a calf injury of some kind. He is now officially questionable to play heading into the weekend, and we still haven’t heard much from the team regarding the severity of this injury or the anticipated timeline for recovery. This is a situation that fantasy managers should be monitoring very closely heading into the weekend, as Brian Robinson Jr. will be a quality start if the star running back has to miss time.
Leo Sells
Christian McCaffrey (calf) working on side field at start of practice
Christian McCaffrey was working on a side field as the 49ers began their Friday practice.
Fantasy Impact
McCaffrey was added to the injury report as a limited participant on Thursday. This remains a situation to monitor as coach Kyle Shanahan addresses the media later in the afternoon.
Ari Koslow
Christian McCaffrey added to practice report
Christian McCaffrey has been added to the San Francisco 49ers practice report as limited due to a calf issue.
Fantasy Impact
A calf injury for star running back Christian McCaffrey is not news fantasy managers want or need to hear. In what sounds eerily familiar to the start of the 2024 season, when his week 1 status was up in the air, fantasy managers will want to keep a close eye on the final injury report for the week. If kept out, it could open up an opportunity for Brian Robinson, recently added from the Washington Commanders.
Paul Brenton
See the latest odds of Christian McCaffrey playing this week 
What the Experts Are Saying
He’s baaaaaack! Not Kyle’s cousin Kyle, but the legendary fantasy RB Christian McCaffrey is ready to regain his fantasy crown after missing almost all of last season. There are a few things worth forgetting, including the fact that Jaws had a sequel, and CMC’s 2024 season is at the top of that list. If he is healthy (which remains TBD given the calf injury that has popped up late in the week), then CMC is a true X factor for fantasy. In 2023, CMC scored 357 fantasy points, which was 18 more than Barkley had last season. This season, the 49ers have one of the easiest schedules for running backs. Add that to the abundance of drama at the receiver position, and CMC should be fed both on the ground and through the air. Off pure usage, he could very well finish as the RB1 on the week against a revamped Seattle defense. But he can also become an injury headache. It seems like managers will need to embrace the risk as early as Week 1 with his questionable status.
– Ellis Johnson
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