Fantasy Football OL & DL Matchups: NFL Week 4 (2025)

As Week 4 kicks off, the spotlight turns to two of the biggest mismatches in the trenches that could swing fantasy football matchups before they even get going.

Fantasy Football Week 4 OL & DL Matchups

Rams OL vs. Colts DL

The Rams’ offensive line enters this matchup as one of the league’s top run-blocking units, ranking No. 1 in rush grade (2.94), according to Fantasy Points Data, heading into their week 4 matchup with the Colts.

They’ve opened lanes well with an adjusted yards before contact of 2.07 per carry (which ranks first in the NFL), but their pass protection has been far shakier — Matthew Stafford has been pressured on 33.7% of his dropbacks, among the highest rates in the NFL.

Indianapolis’ defensive front has not done a great job at generating pressure with a 26.5% pressure rate, which is the fourth-worst mark in the NFL.

If the Rams can stay ahead of the chains and lean on their dominant run game, they’ll mitigate that pressure. However, if Stafford is forced into obvious passing downs, the Colts’ front could exploit their vulnerability. Ultimately, this trench matchup is a classic strength-on-strength battle: An elite Rams run game against an underrated Colts front that does a good job at stopping the run and eliminating explosive runs.

This will be the best run defense the Rams have faced thus far.

Bengals OL vs. Broncos DL

The Bengals’ offensive line has been among the league’s weakest through three games, ranking 32nd overall with just a 0.20 rush grade and a -1.86 pass grade, according to Fantasy Points Data. They’ve struggled heavily in protection, allowing pressure on 46.7% of dropbacks, third-worst in the NFL, which makes life difficult for any quarterback to operate in rhythm. Their run blocking hasn’t been much better, producing only 0.27 adjusted yards before contact per carry, the lowest mark in the NFL.

On the other side, Denver’s defensive line has been steady, generating pressure on 39.2% of snaps, 12th-best in the league, while posting a +7.69% pressure rate over expected, meaning they often outperform expectation in getting to the quarterback.

Against the run, the Broncos allow 1.40 adjusted yards before contact per attempt, eighth-best in the league, showing they can hold up physically at the point of attack. This is a major mismatch in the trenches.