NFL Divisional Playoffs Predictions (49ers vs. Seahawks)

While the fantasy football season is in the rearview, there is plenty of real NFL football remaining. BettingPros will have you covered through the NFL Playoffs with game picks, player props predictions, and more! Here are our top NFL picks and predictions for the NFL Divisional Playoffs: 49ers vs. Seahawks.

NFL Divisional Playoffs Picks & Predictions: 49ers vs. Seahawks

Here are a few of our top picks from Andrew Erickson’s Betting Primer.

NFL Divisional Playoffs Picks

We just saw this matchup two weeks ago, with Seattle dominating the 49ers. Despite a final score of just 13-3, the 49ers were lucky to lose by only 10 points.

Per NFL Next Gen Stats, the 49ers’ offense generated -0.46 expected points added (EPA) per play in their Week 18 loss to the Seahawks, their lowest mark of the season, while posting a 40.5% success rate, their third-lowest mark this season. Christian McCaffrey was limited to 23 yards on eight carries, recording a 25% success rate, his second-lowest of the season, and failed to force a missed tackle on a rushing attempt for the first time in a game since Week 12 of 2022 (minimum eight carries).

As my colleague, Pat Fitzmaurice, put so eloquently in our private Slack chat…

Seahawks beat SF by 10 in Week 18 and it should have been more — Seattle outgained SF by more than a 2-1 margin.

The George Kittle Achilles injury is huge. Their best pass catcher, and when Kittle was out early in the year, CMC barely averaged 3.0 yards per carry.

Huge rest advantage for the Seahawks coming off a bye while the 49ers will be playing on 5 days’ rest.

The SF defense is cheeks.

LOL. I would have used the term “buns” to describe the 49ers’ defense. Still, I felt much better laying the points with Seattle after talking more to Fitzy.

It was my initial lean, but I feel much more bullish.

The 49ers’ defense continues to be banged up, and the rest disadvantage against Seattle is so stark. OT Charles Cross (hamstring) and S Coby Bryant (knee) are expected to return for Saturday’s game against the 49ers.

Safety Ji’Ayir Brown (hamstring) was ruled out of Sunday’s contest against the Eagles. He was a DNP on Tuesday, along with LB Luke Gifford.

LB Dee Winters was limited.

Winters/Brown rank second and 4th respecitvely in defensive snaps played this season.

Since 2023, no team has had a worse ATS record than the 49ers as road underdogs (2-5 ATS). The 49ers are 7-9 ATS with a rest disadvantage since 2023.

Seattle is 2-0 ATS/SU after a bye week (6-3 ATS, 7-2 SU with rest advantage since 2024).

The 49ers are 0-5 ATS as underdogs following a win. They have failed to cover the spread in 16 of their last 21 games following a win.

Per Matt Perrault on the BettingPros Best Early Divisional Round Bets show: Sam Darnold is 13-0 SU and 10-3 ATS as a 6-point-plus favorite. The BP team is all aboard the Seattle wagon.

Go Hawks.

Erickson’s Pick: Seattle -7 and Under 45

Check out the full Betting Primer for 49ers vs. Seahawks

NFL Divisional Playoffs Player Props & Bets

Pat Fitzmaurice shares one of his favorite NFL player props for this week’s game.

Jake Tonges Over 36.5 Receiving Yards

With George Kittle out for the rest of the playoffs with a torn Achilles, Jake Tonges could be an important cog in the 49ers’ passing game the rest of the way.

When Kittle sustained a hamstring injury in the regular season and missed the next five games, Tonges averaged 6.2 targets, 4.4 catches and 41.8 receiving yards. Tonges topped 40 receiving yards in three of those five contests.

After Kittle left Week 1’s contest against the Seahawks in the second quarter, Tonges had three catches for 15 yards and a touchdown.

In addition to being without Kittle, the 49ers could also be missing wide receiver Ricky Pearsall, who missed last week’s game with a knee injury. Pearsall has been practicing on a limited basis this week, but even if he plays, he’s unlikely to be at 100%.

Seattle has struggled against tight ends this season. While the Seahawks allowed the second-fewest receiving yards to wide receivers during the regular season, they allowed the sixth-most receiving yards and fifth-most receptions to tight ends. The Seahawks yielded 63.5 receiving yards per game to tight ends.

The over on Tonges’ receiving yardage looks like a solid percentage play.

And check out all of Fitz’s NFL player props for 49ers vs. Seahawks

Here are even more of our favorite NFL player props via our NFL Prop Bet Cheat Sheet.


Subscribe: Apple Podcasts | Spotify | Google Podcasts | RadioPublic | Breaker | Castbox | Pocket Casts