NFL Wild Card Weekend Predictions (49ers vs. Eagles)

While the fantasy football season is in the rearview, there is plenty of real NFL football remaining. BettingPros will have you covered through the NFL Playoffs with game picks, player props predictions, and more! Here are our top NFL picks and predictions for Wild Card Weekend: 49ers vs. Eagles.

NFL Wild Card Weekend Picks & Predictions: 49ers vs. Eagles

Here are a few of our top picks from Andrew Erickson’s Betting Primer.

NFL Wild Card Weekend Picks

Trends:

The Eagles have won 18 of their last 20 games at Lincoln Financial Field against teams that held a winning record.
Jalen Hurts is 5-0 SU in the playoffs at home (4-1 ATS). Average margin of victory: 21 points; lowest margin of victory: six points.
Each of the 49ers’ last seven road postseason games against NFC opponents has gone under the total points line.
The 49ers have failed to cover the spread in each of their last four postseason games.
The 49ers have won seven straight as favorites.
Eight of the Eagles’ last nine games have gone under the total points line.
The Eagles are 19-9 ATS after a win since 2024 (68% – best mark in the NFL).
The Eagles are 11-21-2 ATS when their defense allowed 20+ points since the start of last season. They covered just 11 spreads when they allowed 20 points on defense.
The Eagles are 22-5-2 ATS when their defense allowed fewer than 20 points since the start of last season (75%).
The 49ers’ team total is listed at 19.5 points.
The Eagles are 5-1 ATS as road underdogs since 2023 (5-1 SU); 1-5 toward the over.
The Eagles are 6-13 over/under at home since the start of 2024 (fewer than 44 points per game).
Twelve of the Eagles’ last 16 home games have gone under the total points line.

Overall:

Joe Pisapia said he’s “all over the Eagles” on Monday’s Wild Card Weekend Lookahead Show, and I’m right there with him. The key for me is that the 49ers just got checked hard by Seattle’s defense in an NFC West championship game, and it wasn’t just the final score — it was the way it happened. The 49ers were lucky to lose by only 10 points.

Per NFL Next Gen Stats, the 49ers’ offense generated -0.46 expected points added (EPA) per play in their Week 18 loss to the Seahawks, their lowest mark of the season, while posting a 40.5% success rate, their third-lowest mark this season. Christian McCaffrey was limited to 23 yards on eight carries, recording a 25% success rate, his second-lowest of the season, and failed to force a missed tackle on a rushing attempt for the first time in a game since Week 12 of 2022 (minimum eight carries).

With more injuries piling up on defense, the 49ers might be running out of gas. Kyle Shanahan deserves all the credit for the way he has coached and won with this undermanned team, but the deck is just too stacked against him in this road playoff spot.

The 49ers’ linebacker room continues to be devastated by injuries.

EVERY 49ers linebacker that made the initial 53 man roster is currently injured!

Fred Warner IR
Dee Winters injured
Tatum Bethune injured
Nick Martin IR
Luke Gifford injured

Stacking injuries at a single position is a killer in the NFL. pic.twitter.com/ckXShvAQ2P

— John Chapman (@JL_Chapman) January 4, 2026

This Eagles-49ers matchup screams similar pressure points that should concern Niners Nation.

San Francisco is traveling across the country. Philadelphia is at home in colder/outdoor conditions. It’s a top-tier Eagles “rested” defense. The Eagles are hoping to have 21 of their 22 starters healthy and ready to go for the playoffs.

Erickson’s Pick: Eagles -4.5 (Lean game total under 44.5 points)

Check out the full Betting Primer for 49ers vs. Eagles

NFL Wild Card Weekend Player Props & Bets

Pat Fitzmaurice shares one of his favorite NFL player props for this week’s game.

Christian McCaffrey Over 57.5 Rushing Yards

Christian McCaffrey got off to a slow start as a runner this season, averaging 56.0 rushing yards a game and 3.1 yards per carry over his first six contests. One reason for the sluggish start might have been an injury to TE George Kittle, an exceptional run blocker. Kittle was injured in Week 1 after playing just 21 snaps and didn’t return until Week 7.

Since Week 7, McCaffrey has averaged 78.7 rushing yards a game and 4.3 yards per carry. He’s run for more than 58 yards in seven of 11 games over that stretch.

Kittle injured his ankle a couple of weeks ago but played in Week 18 and is expected to play this week. San Francisco’s road-grading left tackle, Trent Williams, has a hamstring injury but was able to get in a limited practice on Thursday. It seems like there’s a reasonable chance he’ll suit up for this one.

The Philadelphia run defense is good but not great. The Eagles rank 11th against the run in DVOA and have allowed the 15th-most rushing yards to running backs this season.

McCaffrey is averaging 18.3 carries a game this season. Volume should carry the day here and get McCaffrey over 58.5 rushing yards.

And check out all of Fitz’s NFL player props for 49ers vs. Eagles

Here are even more of our favorite NFL player props via our NFL Prop Bet Cheat Sheet.