Adam Schefter reports that 49ers QB Jimmy Garoppolo has been ruled out for Week 5 due to the calf injury he suffered in Week 4 against the Seahawks. (Adam Schefter on Twitter)
Fantasy Impact
With Garoppolo ruled out for Sunday's matchup with the Cardinals, this could be the changing of the guard in San Francisco. The Arizona D/ST ranks in the bottom of the NFL against in rushing defense, and Lance could very well take the reigns and "run" with them.