Kyren Williams Week 10 Outlook - Rams at 49ers

By Ellis Johnson (FantasyPros), Mon, Nov 3rd 2025, 1:39pm EST

Last week was just another RB1 day for Kyren Williams. Williams may not be the most flashy running back, but he is the lead back on a great offense. In Week 9, he had 25 carries for 114 yards and a score against the Saints. Despite Sean McVay sticking to his word and splitting the work near 65-35 between Williams and Blake Corum, Williams has maintained his fantasy value. He may not be the top-tier RB1 we have seen in the past, but his guaranteed work on a great offense leaves him flirting with RB1 numbers each week. This week, they face a beat-up 49ers defense that has been league average against fantasy running backs. Kyren is a very safe play each week, and could have a good day against a defense struggling with multiple injuries.