Kyren Williams Week 1 Outlook - 49ers at Rams

By Derek Brown (FantasyPros), Sun, Sep 13th 2026, 12:44pm EDT

Last year, Kyren Williams was the RB10 in fantasy points per game after seasons as the RB10 and RB2 in fantasy points per game. Williams had to deal with more work for Blake Corum last year, but he still retained his lead role overall and in the red zone. In Weeks 7-18, Williams still saw 63% of the red zone rushing attempts while Corum helped him with the heavy lifting on early downs in between the 20s. With the workload lightened a tad, Williams did post improved rushing efficiency metrics, ranking 21st in explosive run rate, 25th in missed tackle rate, and 18th in yards after contact per attempt. Williams should enjoy a wonderful Week 1 against the 49ers. Last year, San Francisco allowed the highest rushing success rate, the tenth-most yards before contact per attempt, and had the seventh-lowest hit rate at or behind the line of scrimmage.