| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 7.7 | 18.9 | 30.4 | 28.3 | 16.5 | 19.7 | 33 | 21.6 | 22 | 176.1 | ||||||||||
| 2 | James Conner | RB | ARI | 17.8 | 19.6 | 10.2 | 7.6 | 12.4 | 14.2 | 37.8 | 13.9 | 16.7 | 133.5 | ||||||||||
| 3 | Najee Harris | RB | LAC | 21.2 | 18.1 | 21.2 | 21.7 | BYE | 19.5 | 15.3 | 15.3 | 18.9 | 132.3 | ||||||||||
| 4 | Derrick Henry | RB | BAL | 17.9 | 24.7 | 31 | 34.6 | 15.4 | 6.8 | - | - | 21.7 | 130.4 | ||||||||||
| 5 | Austin Ekeler | RB | WAS | 19.7 | 28 | 30.4 | 7.5 | - | 21.4 | 9.7 | 13.4 | 18.6 | 130.1 | ||||||||||
| 6 | Ezekiel Elliott | RB | FA | 25.1 | 20.3 | 24.2 | 15.4 | - | 9.3 | 11.1 | 19.3 | 17.8 | 124.7 | ||||||||||
| 7 | Alvin Kamara | RB | NO | 19.3 | 12 | 26.7 | BYE | 28.9 | 15.1 | 18.4 | - | 20.1 | 120.4 | ||||||||||
| 8 | Joe Mixon | RB | HOU | 9.9 | 13.2 | 10 | 23.8 | 11.9 | 23.1 | 25.5 | BYE | 16.8 | 117.4 |