| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Austin Ekeler | RB | WAS | 9.3 | 31.9 | 33.9 | 19.3 | 30.7 | - | 20.6 | 9.8 | 22.2 | 155.5 | ||||||||||
| 2 | Derrick Henry | RB | BAL | 22.8 | 22.2 | 26.2 | - | 15.3 | 35.3 | 23.5 | 7.7 | 21.9 | 153 | ||||||||||
| 3 | Josh Jacobs | RB | GB | 12.2 | 32 | 27.8 | - | 35 | 6.4 | 10.2 | 19.6 | 20.5 | 143.2 | ||||||||||
| 4 | Christian McCaffrey | RB | SF | 12.5 | 21.3 | 19.9 | 19.3 | 7.2 | 36.3 | BYE | 15.7 | 18.9 | 132.2 | ||||||||||
| 5 | Nick Chubb | RB | HOU | 17.3 | 19.7 | 25.4 | 7.5 | 17.7 | 24.9 | - | 13.6 | 18 | 126.1 | ||||||||||
| 6 | Joe Mixon | RB | HOU | 5.3 | 15.4 | 10.3 | 14.8 | 16.6 | 9.4 | 53.1 | - | 17.8 | 124.9 | ||||||||||
| 7 | Saquon Barkley | RB | PHI | 20.6 | 17.2 | 18.1 | 17 | 15.5 | 13.7 | - | 22.5 | 17.8 | 124.6 | ||||||||||
| 8 | Rhamondre Stevenson | RB | NE | 18.1 | 10.9 | 18.5 | 23.1 | 19.8 | 17.8 | 14.5 | BYE | 17.5 | 122.7 |