| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 37.9 | 6.3 | 26.3 | 28.9 | 44.7 | 19.7 | - | 25.5 | 36.1 | 23.1 | 24.6 | 27.3 | 273.1 | ||||||
| 2 | Dalvin Cook | RB | FA | 25 | 26.6 | 22.3 | 16 | 22.8 | 12.4 | 27.4 | 25.6 | 13.6 | 27.8 | 14.2 | 21.2 | 233.7 | ||||||
| 3 | Aaron Jones Sr. | RB | MIN | 4.4 | 23 | 14.8 | 14.8 | 45.7 | 6 | 16.3 | 38.1 | 3.4 | 27.3 | - | 19.4 | 193.8 | ||||||
| 4 | Austin Ekeler | RB | WAS | 36.4 | 20.3 | 11.6 | 26.7 | 14.8 | 4.3 | 22 | 9.2 | 11.3 | 11.8 | 17.2 | 16.9 | 185.6 | ||||||
| 5 | Derrick Henry | RB | BAL | 28.4 | 16.4 | 11.1 | 11.3 | 13.8 | 3.8 | 17.3 | 6.8 | 23.4 | 32.1 | - | 16.4 | 164.4 | ||||||
| 6 | Ezekiel Elliott | RB | FA | 12.8 | 19 | 14.9 | 13.5 | 16.1 | 23.8 | 23.7 | - | 13.9 | 7.3 | 18.3 | 16.3 | 163.3 | ||||||
| 7 | Nick Chubb | RB | HOU | 10 | 17.8 | 15.1 | 37.8 | 10.4 | 26.4 | - | 10.3 | 11.1 | 13.1 | 9.2 | 16.1 | 161.2 | ||||||
| 8 | Josh Jacobs | RB | GB | 23.8 | 9.9 | 4.4 | 11.8 | 27.8 | - | 14.9 | 9.1 | 24 | 17.6 | 11.9 | 15.5 | 155.2 |