| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jahmyr Gibbs | RB | DET | 17.1 | 49.9 | 10.1 | 33.5 | 7.8 | 23.7 | 118.4 | |||||||||||||
| 2 | Bijan Robinson | RB | ATL | 28.3 | 13.7 | 27.8 | 8.4 | 25.5 | 20.7 | 103.7 | |||||||||||||
| 3 | James Cook III | RB | BUF | 18.9 | 20.4 | 17.2 | 10.1 | 30.1 | 19.3 | 96.7 | |||||||||||||
| 4 | Travis Etienne Jr. | RB | JAC | 19.3 | 19.1 | 4.6 | 20.7 | 30 | 18.7 | 93.7 | |||||||||||||
| 5 | Christian McCaffrey | RB | SF | 32.6 | 23.7 | 15.4 | BYE | 15.2 | 21.7 | 86.9 | |||||||||||||
| 6 | Derrick Henry | RB | BAL | 19.2 | 21.8 | 16.9 | 10.7 | 10 | 15.7 | 78.6 | |||||||||||||
| 6 | TreVeyon Henderson | RB | NE | 29.8 | 9.6 | 10.1 | BYE | 29.1 | 19.7 | 78.6 | |||||||||||||
| 8 | Kenneth Gainwell | RB | PIT | 26 | 15.2 | 5.5 | 13.2 | 16.1 | 15.2 | 76 |