| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 18.7 | 19.7 | 19 | 23.1 | 23.9 | 20.6 | 35.6 | 8.3 | 31.8 | 13.6 | 32.6 | 23.7 | 15.4 | 22 | 286 | |||||
| 2 | Jonathan Taylor | RB | IND | 11.3 | 28.5 | 31.3 | 12.1 | 30.1 | 21.7 | 32.7 | 36.4 | 6.7 | 48.1 | BYE | 7.6 | 13.6 | 23.3 | 280.1 | |||||
| 3 | Jahmyr Gibbs | RB | DET | 10 | 17.9 | 24.4 | 16.7 | 15.7 | 7 | 35.3 | BYE | 4.3 | 36.7 | 17.1 | 49.9 | 10.1 | 20.4 | 245.1 | |||||
| 4 | Bijan Robinson | RB | ATL | 21.4 | 18.3 | 13.6 | 26.1 | BYE | 32.8 | 18.2 | 4.3 | 13.6 | 9.8 | 28.3 | 13.7 | 27.8 | 19 | 227.9 | |||||
| 5 | De'Von Achane | RB | MIA | 15 | 22.2 | 12.6 | 16.6 | 13.6 | 29 | 11.3 | 17.6 | 13.6 | 37.5 | 19 | BYE | 19.4 | 19 | 227.4 | |||||
| 6 | James Cook III | RB | BUF | 18.7 | 26 | 19.3 | 21 | 4.9 | 8.7 | BYE | 33.6 | 13 | 8.2 | 18.9 | 20.4 | 17.2 | 17.5 | 209.9 | |||||
| 7 | Javonte Williams | RB | DAL | 19.4 | 22 | 9.7 | 17.5 | 26.4 | 5.9 | 18.3 | 17.4 | 6.8 | BYE | 9.8 | 11.1 | 15.5 | 15 | 179.8 | |||||
| 8 | Josh Jacobs | RB | GB | 13.5 | 14.4 | 9.9 | 29.7 | BYE | 29.5 | 18.3 | 12 | 18 | 17.2 | 4 | - | 9.6 | 16 | 176.1 |