| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Todd Gurley II | RB | FA | 23.7 | 32.3 | 24.6 | 25.6 | 33.3 | 36.5 | 30.6 | 33.5 | 19.9 | 25 | 28.5 | 285 | |||||||
| 2 | Alvin Kamara | RB | NO | 43.1 | 17.9 | 34 | 41.1 | 6.9 | BYE | 15.5 | 26.6 | 33.6 | 26.2 | 27.2 | 244.9 | |||||||
| 3 | James Conner | RB | ARI | 33.9 | 19.5 | 14.5 | 9.4 | 34.5 | 28.9 | - | 38.2 | 29.3 | 14.3 | 24.7 | 222.5 | |||||||
| 4 | Saquon Barkley | RB | PHI | 20.8 | 24.8 | 22.7 | 22 | 28.9 | 37.9 | 26.4 | 20.1 | BYE | 14 | 24.2 | 217.6 | |||||||
| 5 | Kareem Hunt | RB | KC | 4.9 | 15 | 16.4 | 26.5 | 16.4 | 29.5 | 37.1 | 19.6 | 33.1 | 11.6 | 21 | 210.1 | |||||||
| 6 | Melvin Gordon III | RB | FA | 27.6 | 30.6 | 16.4 | 30.9 | 22 | 35 | - | - | 19.3 | 27.5 | 26.2 | 209.3 | |||||||
| 7 | James White | RB | FA | 15.6 | 15.4 | 14.1 | 31.2 | 23.7 | 14.2 | 29.7 | 25.4 | 28.3 | 7.6 | 20.5 | 205.2 | |||||||
| 8 | Christian McCaffrey | RB | SF | 13.5 | 27.9 | 21.4 | - | 20.3 | 13.6 | 14 | 21.6 | 32.7 | 36.8 | 22.4 | 201.8 |