| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 42.9 | 7.3 | 27.8 | 33.9 | 47.7 | 21.7 | - | 27.5 | 37.6 | 26.1 | 30.3 | 272.5 | |||||||
| 2 | Dalvin Cook | RB | FA | 26 | 28.1 | 24.3 | 19 | 25.8 | 13.4 | 27.9 | 28.1 | 15.6 | 31.3 | 24 | 239.5 | |||||||
| 3 | Aaron Jones Sr. | RB | MIN | 4.9 | 25 | 15.3 | 17.8 | 49.2 | 8 | 18.3 | 41.6 | 3.9 | 27.3 | 21.1 | 211.3 | |||||||
| 4 | Austin Ekeler | RB | WAS | 39.4 | 23.3 | 15.1 | 29.2 | 22.3 | 5.8 | 25.5 | 10.2 | 13.3 | 12.8 | 19.7 | 196.9 | |||||||
| 5 | Derrick Henry | RB | BAL | 28.9 | 17.4 | 11.6 | 11.8 | 13.8 | 4.3 | 17.8 | 7.3 | 24.9 | 33.1 | 17.1 | 170.9 | |||||||
| 6 | Nick Chubb | RB | HOU | 11.5 | 19.8 | 17.1 | 39.3 | 10.9 | 28.9 | - | 10.8 | 13.1 | 14.1 | 18.4 | 165.5 | |||||||
| 7 | Chris Carson | RB | FA | 24 | 9.7 | 4 | 18.5 | 19.3 | 25.9 | 10.4 | 15 | 13.3 | 19.1 | 15.9 | 159.2 | |||||||
| 8 | Ezekiel Elliott | RB | FA | 13.3 | 20 | 15.9 | 16.5 | 17.1 | 26.3 | 26.7 | - | 13.9 | 8.3 | 17.6 | 158 |