| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Todd Gurley II | RB | FA | 33.3 | 36.5 | 30.6 | 33.5 | 19.9 | 25 | 29.8 | 178.8 | |||||||||||
| 2 | Kareem Hunt | RB | KC | 16.4 | 29.5 | 37.1 | 19.6 | 33.1 | 11.6 | 24.6 | 147.3 | |||||||||||
| 3 | James Conner | RB | ARI | 34.5 | 28.9 | - | 38.2 | 29.3 | 14.3 | 29 | 145.2 | |||||||||||
| 4 | Christian McCaffrey | RB | SF | 20.3 | 13.6 | 14 | 21.6 | 32.7 | 36.8 | 23.2 | 139 | |||||||||||
| 5 | James White | RB | FA | 23.7 | 14.2 | 29.7 | 25.4 | 28.3 | 7.6 | 21.5 | 128.9 | |||||||||||
| 6 | Saquon Barkley | RB | PHI | 28.9 | 37.9 | 26.4 | 20.1 | BYE | 14 | 25.5 | 127.3 | |||||||||||
| 7 | Alvin Kamara | RB | NO | 6.9 | BYE | 15.5 | 26.6 | 33.6 | 26.2 | 21.8 | 108.8 | |||||||||||
| 8 | Melvin Gordon III | RB | FA | 22 | 35 | - | - | 19.3 | 27.5 | 26 | 103.8 |