| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 17.6 | 6.3 | 8.2 | 20.4 | 31.9 | 28.8 | 18 | 21.2 | 34 | 24.6 | 53.4 | 24 | 264.4 | |||||||
| 2 | Austin Ekeler | RB | WAS | 11.7 | 22.5 | 22.7 | 29.5 | 32.9 | 9.5 | - | 24.4 | 11.2 | 14.9 | 41.5 | 22.1 | 220.8 | |||||||
| 3 | Derrick Henry | RB | BAL | 10.7 | 47.7 | 19.4 | 25.7 | 31 | 35.6 | 16.4 | 6.8 | - | - | - | 24.2 | 193.3 | |||||||
| 4 | Najee Harris | RB | LAC | 5.9 | 19.1 | 28.2 | 21.1 | 22.2 | 24.7 | BYE | 21 | 16.8 | 17.3 | 16.9 | 19.3 | 193.2 | |||||||
| 5 | D'Andre Swift | RB | CHI | 24.4 | 11.8 | 23.7 | 8.9 | 22.4 | 17.7 | 28.4 | 8.1 | - | 16.5 | 22.6 | 18.5 | 184.5 | |||||||
| 6 | Joe Mixon | RB | HOU | 25 | 8.1 | 10.4 | 13.7 | 10.5 | 26.3 | 11.9 | 25.1 | 28 | BYE | 24.3 | 18.3 | 183.3 | |||||||
| 7 | Ezekiel Elliott | RB | FA | 5.9 | 17.7 | 26.6 | 20.3 | 25.2 | 18.9 | - | 11.3 | 12.6 | 20.8 | 12.8 | 17.2 | 172.1 | |||||||
| 8 | James Conner | RB | ARI | 5.3 | 2.6 | 18.3 | 20.6 | 10.7 | 8.1 | 12.4 | 14.2 | 40.3 | 15.4 | 20.9 | 15.3 | 168.8 |