| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 35.8 | 23.5 | 8.7 | 25.4 | 23.3 | 93.4 | ||||||||||||||
| 2 | Tony Pollard | RB | TEN | 33.7 | - | 21.8 | 36.9 | 30.8 | 92.4 | ||||||||||||||
| 3 | Joe Mixon | RB | HOU | 12.9 | 55.1 | - | 9.2 | 25.7 | 77.2 | ||||||||||||||
| 4 | Christian McCaffrey | RB | SF | 40.3 | BYE | 17.7 | 17.6 | 25.2 | 75.6 | ||||||||||||||
| 5 | Alvin Kamara | RB | NO | 42.8 | 9.2 | 7.5 | 12.9 | 18.1 | 72.4 | ||||||||||||||
| 6 | Dalvin Cook | RB | FA | 25.1 | 13.6 | 23.6 | 7.2 | 17.4 | 69.5 | ||||||||||||||
| 7 | Jamaal Williams | RB | FA | 22.6 | 10.1 | 11.9 | 24.4 | 17.3 | 69 | ||||||||||||||
| 8 | Aaron Jones Sr. | RB | MIN | 19.7 | 6.5 | 23.6 | 14 | 16 | 63.8 |