| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jahmyr Gibbs | RB | DET | 19.6 | 55.4 | 11.6 | 37 | 30.9 | 123.6 | ||||||||||||||
| 2 | Bijan Robinson | RB | ATL | 30.3 | 14.7 | 30.3 | 9.4 | 21.2 | 84.7 | ||||||||||||||
| 3 | Christian McCaffrey | RB | SF | 35.1 | 27.2 | 17.4 | BYE | 26.6 | 79.7 | ||||||||||||||
| 4 | James Cook III | RB | BUF | 20.4 | 21.9 | 18.7 | 11.1 | 18 | 72.1 | ||||||||||||||
| 5 | Derrick Henry | RB | BAL | 20.2 | 22.8 | 17.4 | 11.2 | 17.9 | 71.6 | ||||||||||||||
| 6 | Chase Brown | RB | CIN | 18.7 | 15 | 18.3 | 18.5 | 17.6 | 70.5 | ||||||||||||||
| 7 | Kenneth Gainwell | RB | PIT | 29.5 | 18.2 | 6.5 | 16.2 | 17.6 | 70.4 | ||||||||||||||
| 8 | Travis Etienne Jr. | RB | JAC | 19.3 | 20.6 | 5.1 | 21.2 | 16.6 | 66.2 |