| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Austin Ekeler | RB | WAS | 11.2 | 18.4 | 13.3 | 34.9 | 35.9 | 24.3 | 36.7 | - | 24.1 | 24.9 | 198.8 | |||||||||
| 2 | Joe Mixon | RB | HOU | 21.5 | 11.3 | 6.8 | 17.4 | 11.8 | 16.8 | 18.1 | 12.9 | 55.1 | 19.1 | 171.7 | |||||||||
| 3 | Derrick Henry | RB | BAL | 8.2 | 8.5 | 25.3 | 23.7 | 27.2 | - | 16.8 | 35.8 | 23.5 | 21.1 | 169 | |||||||||
| 4 | Christian McCaffrey | RB | SF | 15.7 | 16.8 | 13.5 | 25.8 | 23.4 | 22.8 | 8.2 | 40.3 | BYE | 20.8 | 166.5 | |||||||||
| 5 | Nick Chubb | RB | HOU | 15.3 | 32.3 | 17.3 | 20.7 | 25.4 | 8 | 18.7 | 25.4 | - | 20.4 | 163.1 | |||||||||
| 6 | Saquon Barkley | RB | PHI | 33.4 | 11.8 | 22.6 | 18.2 | 19.6 | 18.5 | 17.5 | 15.2 | - | 19.6 | 156.8 | |||||||||
| 7 | Josh Jacobs | RB | GB | 8.3 | 9.1 | 14.7 | 34.5 | 30.3 | - | 36.5 | 7.4 | 11.7 | 19.1 | 152.5 | |||||||||
| 8 | Rhamondre Stevenson | RB | NE | 4.7 | 6.1 | 20.1 | 12.9 | 19.5 | 25.1 | 23.8 | 21.3 | 16 | 16.6 | 149.5 |