| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 25.9 | 22.5 | 22.9 | 48.7 | 13.8 | 14.2 | 22.6 | 29.8 | BYE | 25.1 | 200.4 | |||||||||
| 2 | Raheem Mostert | RB | LV | 13 | 25.7 | 45.2 | 5.5 | 15.8 | 34.2 | 6.1 | 10.6 | 14.5 | 19 | 170.6 | |||||||||
| 3 | Travis Etienne Jr. | RB | JAC | 21.4 | 6.2 | 17.8 | 10.2 | 36.4 | 23.3 | 22.7 | 25.9 | BYE | 20.5 | 163.9 | |||||||||
| 4 | Josh Jacobs | RB | GB | 9.1 | 9.9 | 11 | 27.9 | 19.9 | 11.3 | 5.1 | 16.8 | 21.8 | 14.8 | 132.8 | |||||||||
| 5 | D'Andre Swift | RB | CHI | 1.3 | 27.1 | 14.8 | 17.9 | 16.8 | 17.8 | 10.5 | 14.4 | 9.4 | 14.4 | 130 | |||||||||
| 6 | Zack Moss | RB | FA | - | 20.7 | 22.5 | 9 | 33.5 | 17.9 | 7.2 | 14.4 | 2.6 | 16 | 127.8 | |||||||||
| 7 | Alvin Kamara | RB | NO | - | - | - | 21.4 | 18.7 | 17.4 | 29.3 | 27 | 11 | 20.8 | 124.8 | |||||||||
| 8 | Derrick Henry | RB | BAL | 13.9 | 18.5 | 2 | 24.4 | 9.2 | 19.3 | - | 16.2 | 19.2 | 15.3 | 122.7 |