| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Austin Ekeler | RB | WAS | 34.9 | 35.9 | 24.3 | 36.7 | - | 24.1 | 31.2 | 155.9 | ||||||||||||
| 2 | Joe Mixon | RB | HOU | 17.4 | 11.8 | 16.8 | 18.1 | 12.9 | 55.1 | 22 | 132.1 | ||||||||||||
| 3 | Derrick Henry | RB | BAL | 23.7 | 27.2 | - | 16.8 | 35.8 | 23.5 | 25.4 | 127 | ||||||||||||
| 4 | Christian McCaffrey | RB | SF | 25.8 | 23.4 | 22.8 | 8.2 | 40.3 | BYE | 24.1 | 120.5 | ||||||||||||
| 5 | Josh Jacobs | RB | GB | 34.5 | 30.3 | - | 36.5 | 7.4 | 11.7 | 24.1 | 120.4 | ||||||||||||
| 6 | Rhamondre Stevenson | RB | NE | 12.9 | 19.5 | 25.1 | 23.8 | 21.3 | 16 | 19.8 | 118.6 | ||||||||||||
| 7 | Alvin Kamara | RB | NO | - | 23.4 | 18.4 | 17.5 | 42.8 | 9.2 | 22.3 | 111.3 | ||||||||||||
| 8 | Leonard Fournette | RB | FA | 18.4 | 35.9 | 22.1 | 4.6 | 14.8 | 11 | 17.8 | 106.8 |