| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Joe Mixon | RB | HOU | 16.8 | 18.1 | 12.9 | 55.1 | 25.7 | 102.9 | ||||||||||||||
| 2 | Alvin Kamara | RB | NO | 18.4 | 17.5 | 42.8 | 9.2 | 22 | 87.9 | ||||||||||||||
| 3 | Kenneth Walker III | RB | SEA | 19 | 28.7 | 12.2 | 27.9 | 22 | 87.8 | ||||||||||||||
| 4 | Rhamondre Stevenson | RB | NE | 25.1 | 23.8 | 21.3 | 16 | 21.6 | 86.2 | ||||||||||||||
| 5 | Austin Ekeler | RB | WAS | 24.3 | 36.7 | - | 24.1 | 28.4 | 85.1 | ||||||||||||||
| 6 | Travis Etienne Jr. | RB | JAC | 12.8 | 18.9 | 25.2 | 26.6 | 20.9 | 83.5 | ||||||||||||||
| 7 | Derrick Henry | RB | BAL | - | 16.8 | 35.8 | 23.5 | 25.4 | 76.1 | ||||||||||||||
| 8 | Christian McCaffrey | RB | SF | 22.8 | 8.2 | 40.3 | BYE | 23.8 | 71.3 |