| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 7.2 | 17.4 | 28.9 | 27.8 | 15 | 18.2 | 32 | 18.6 | 20.6 | 165.1 | ||||||||||
| 2 | James Conner | RB | ARI | 17.3 | 18.6 | 9.7 | 7.1 | 12.4 | 14.2 | 35.3 | 12.4 | 15.9 | 127 | ||||||||||
| 3 | Derrick Henry | RB | BAL | 16.4 | 23.7 | 31 | 33.6 | 14.4 | 6.8 | - | - | 21 | 125.9 | ||||||||||
| 4 | Austin Ekeler | RB | WAS | 16.7 | 26.5 | 27.9 | 5.5 | - | 18.4 | 8.2 | 11.9 | 16.4 | 115.1 | ||||||||||
| 5 | Ezekiel Elliott | RB | FA | 23.6 | 20.3 | 23.2 | 11.9 | - | 7.3 | 9.6 | 17.8 | 16.2 | 113.7 | ||||||||||
| 6 | Najee Harris | RB | LAC | 14.2 | 15.1 | 20.2 | 18.7 | BYE | 18 | 13.8 | 13.3 | 16.2 | 113.3 | ||||||||||
| 7 | Joe Mixon | RB | HOU | 9.4 | 12.7 | 9.5 | 21.3 | 11.9 | 21.1 | 23 | BYE | 15.6 | 108.9 | ||||||||||
| 8 | Alvin Kamara | RB | NO | 17.8 | 12 | 24.2 | BYE | 23.9 | 13.6 | 16.4 | - | 18 | 107.9 |