| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Todd Gurley II | RB | FA | 20.7 | 29.3 | 19.6 | 21.6 | 29.3 | 34.5 | 26.6 | 27.5 | 13.9 | 22 | 9.4 | - | 23.1 | 254.4 | |||||
| 2 | Alvin Kamara | RB | NO | 34.1 | 11.9 | 19 | 36.1 | 3.9 | BYE | 13.5 | 19.6 | 29.6 | 22.2 | 16.8 | 9.8 | 19.7 | 216.5 | |||||
| 3 | Saquon Barkley | RB | PHI | 18.8 | 10.8 | 17.7 | 16 | 24.9 | 28.9 | 17.4 | 11.1 | BYE | 10 | 33.2 | 26.2 | 19.5 | 215 | |||||
| 4 | Melvin Gordon III | RB | FA | 18.6 | 24.6 | 14.4 | 23.9 | 18 | 33 | - | - | 18.3 | 22.5 | 15.6 | 18.6 | 20.8 | 207.5 | |||||
| 5 | Kareem Hunt | RB | KC | 4.9 | 14 | 16.4 | 23.5 | 15.4 | 24.5 | 32.1 | 14.6 | 32.1 | 9.6 | 17.1 | BYE | 18.6 | 204.2 | |||||
| 6 | James Conner | RB | ARI | 28.9 | 14.5 | 9.5 | 6.4 | 30.5 | 24.9 | - | 33.2 | 22.3 | 13.3 | 4.9 | 7.5 | 17.8 | 195.9 | |||||
| 7 | Christian McCaffrey | RB | SF | 7.5 | 13.9 | 19.4 | - | 15.3 | 6.6 | 8 | 17.6 | 27.7 | 31.8 | 11 | 35.7 | 17.7 | 194.5 | |||||
| 8 | Ezekiel Elliott | RB | FA | 14.6 | 14.7 | 11.8 | 30 | 8.4 | 17.7 | 4.2 | - | 11.2 | 30.7 | 26.1 | 20.3 | 17.2 | 189.7 |