| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 29.4 | 32.9 | 15.6 | 25.2 | 25.8 | 103.1 | ||||||||||||||
| 2 | Chuba Hubbard | RB | CAR | 22.9 | 18.1 | 13.5 | 10.3 | 16.2 | 64.8 | ||||||||||||||
| 3 | D'Andre Swift | RB | CHI | 4.2 | 22.5 | 18 | 17.9 | 15.7 | 62.6 | ||||||||||||||
| 4 | Kyren Williams | RB | LAR | 29.6 | 16.4 | 14.5 | BYE | 20.2 | 60.5 | ||||||||||||||
| 5 | Chase Brown | RB | CIN | 6.9 | 21.2 | 13.4 | 12.4 | 13.5 | 53.9 | ||||||||||||||
| 6 | David Montgomery | RB | DET | 18.2 | 14 | BYE | 20 | 17.4 | 52.2 | ||||||||||||||
| 7 | Kenneth Walker III | RB | SEA | - | 29.6 | 7.6 | 12.9 | 16.7 | 50.1 | ||||||||||||||
| 8 | Alvin Kamara | RB | NO | 12.7 | 17.9 | 6.6 | 12.4 | 12.4 | 49.6 |