| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 9.8 | 27.5 | 29.8 | 9.6 | 28.6 | 19.7 | 31.2 | 35.4 | 5.7 | 46.6 | BYE | 6.6 | 12.1 | 21.9 | 262.6 | |||||
| 2 | Christian McCaffrey | RB | SF | 14.2 | 16.7 | 14 | 20.1 | 19.9 | 17.1 | 32.1 | 6.8 | 29.3 | 9.6 | 30.1 | 20.2 | 13.4 | 18.7 | 243.5 | |||||
| 3 | Jahmyr Gibbs | RB | DET | 5 | 16.4 | 21.9 | 15.7 | 14.7 | 6.5 | 33.8 | BYE | 2.8 | 35.2 | 14.6 | 44.4 | 8.6 | 18.3 | 219.6 | |||||
| 4 | Bijan Robinson | RB | ATL | 18.4 | 16.8 | 11.1 | 24.1 | BYE | 29.8 | 15.2 | 2.8 | 9.6 | 8.8 | 26.3 | 12.7 | 25.3 | 16.7 | 200.9 | |||||
| 5 | De'Von Achane | RB | MIA | 13.5 | 18.2 | 9.1 | 16.1 | 10.6 | 27 | 9.8 | 15.1 | 10.6 | 34.5 | 16.5 | BYE | 19.4 | 16.7 | 200.4 | |||||
| 6 | James Cook III | RB | BUF | 16.2 | 25.5 | 17.8 | 19.5 | 4.9 | 8.7 | BYE | 33.6 | 12.5 | 5.7 | 17.4 | 18.9 | 15.7 | 16.4 | 196.4 | |||||
| 7 | Javonte Williams | RB | DAL | 18.4 | 19 | 7.2 | 16 | 25.9 | 3.4 | 17.8 | 16.9 | 6.3 | BYE | 9.3 | 10.1 | 14 | 13.7 | 164.3 | |||||
| 8 | Derrick Henry | RB | BAL | 28.2 | 2.3 | 9.7 | 5.8 | 9.3 | 13 | BYE | 19.1 | 12.1 | 8.4 | 18.2 | 20.8 | 16.4 | 13.6 | 163.3 |