| Player | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | TTL | AVG |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Carson Steele | KC | 5 | 14 | 46 | 11 | 16 | bye | 14 | 8 | 14 | 13 | 8 | 11 | 3 | 6 | 3 | 6 | 0 | 23 | 201 | 12.6 |
| Isiah Pacheco | KC | 43 | 43 | 0 | 0 | 0 | bye | 0 | 0 | 0 | 0 | 0 | 0 | 26 | 32 | 28 | 26 | 20 | 0 | 218 | 31.1 |
| Samaje Perine | KC | 8 | 9 | 28 | 25 | 21 | bye | 15 | 22 | 24 | 16 | 11 | 24 | 18 | 17 | 19 | 14 | 12 | 13 | 296 | 17.4 |
| Derrick Henry | BAL | 37 | 30 | 37 | 37 | 39 | 43 | 34 | 35 | 35 | 39 | 30 | 39 | 37 | bye | 27 | 46 | 41 | 49 | 635 | 37.4 |
| Justice Hill | BAL | 43 | 35 | 26 | 20 | 41 | 26 | 27 | 34 | 19 | 22 | 30 | 26 | 36 | bye | 22 | 7 | 0 | 0 | 414 | 27.6 |
| Kenneth Gainwell | PHI | 15 | 7 | 14 | 25 | bye | 13 | 24 | 9 | 22 | 22 | 13 | 23 | 7 | 14 | 31 | 14 | 15 | 33 | 301 | 17.7 |
| Saquon Barkley | PHI | 61 | 64 | 58 | 32 | bye | 49 | 35 | 50 | 57 | 35 | 58 | 50 | 49 | 44 | 49 | 61 | 49 | 0 | 801 | 50.1 |
| Josh Jacobs | GB | 49 | 47 | 33 | 46 | 44 | 46 | 39 | 45 | 36 | bye | 37 | 38 | 42 | 40 | 48 | 28 | 40 | 20 | 678 | 39.9 |
| Emanuel Wilson | GB | 16 | 13 | 26 | 30 | 15 | 23 | 12 | 12 | 13 | bye | 3 | 15 | 4 | 3 | 6 | 25 | 20 | 27 | 263 | 15.5 |
| Will Shipley | PHI | 4 | 0 | 0 | 1 | bye | 0 | 9 | 2 | 1 | 11 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 36 | 65 | 8.1 |