| Miami Dolphins at Cincinnati Bengals | Thursday, September 29th, 2022 at 8:15pm ET |
Bye Week: none |
| Minnesota Vikings at New Orleans Saints | Sunday, October 2nd, 2022 at 9:30am ET | |
| Buffalo Bills at Baltimore Ravens | Sunday, October 2nd, 2022 at 1:00pm ET | |
| Cleveland Browns at Atlanta Falcons | Sunday, October 2nd, 2022 at 1:00pm ET | |
| New York Jets at Pittsburgh Steelers | Sunday, October 2nd, 2022 at 1:00pm ET | |
| Washington Commanders at Dallas Cowboys | Sunday, October 2nd, 2022 at 1:00pm ET | |
| Jacksonville Jaguars at Philadelphia Eagles | Sunday, October 2nd, 2022 at 1:00pm ET | |
| Chicago Bears at New York Giants | Sunday, October 2nd, 2022 at 1:00pm ET | |
| Los Angeles Chargers at Houston Texans | Sunday, October 2nd, 2022 at 1:00pm ET | |
| Tennessee Titans at Indianapolis Colts | Sunday, October 2nd, 2022 at 1:00pm ET | |
| Seattle Seahawks at Detroit Lions | Sunday, October 2nd, 2022 at 1:00pm ET | |
| Arizona Cardinals at Carolina Panthers | Sunday, October 2nd, 2022 at 4:05pm ET | |
| New England Patriots at Green Bay Packers | Sunday, October 2nd, 2022 at 4:25pm ET | |
| Denver Broncos at Las Vegas Raiders | Sunday, October 2nd, 2022 at 4:25pm ET | |
| Kansas City Chiefs at Tampa Bay Buccaneers | Sunday, October 2nd, 2022 at 8:20pm ET | |
| Los Angeles Rams at San Francisco 49ers | Monday, October 3rd, 2022 at 8:15pm ET |
See the Full Season Schedule
