| Indianapolis Colts at Houston Texans | Sunday, December 6th, 2020 at 1:00pm ET | Bye Week: CAR, TB |
| Jacksonville Jaguars at Minnesota Vikings | Sunday, December 6th, 2020 at 1:00pm ET | |
| Las Vegas Raiders at New York Jets | Sunday, December 6th, 2020 at 1:00pm ET | |
| New Orleans Saints at Atlanta Falcons | Sunday, December 6th, 2020 at 1:00pm ET | |
| Cincinnati Bengals at Miami Dolphins | Sunday, December 6th, 2020 at 1:00pm ET | |
| Cleveland Browns at Tennessee Titans | Sunday, December 6th, 2020 at 1:00pm ET | |
| Detroit Lions at Chicago Bears | Sunday, December 6th, 2020 at 1:00pm ET | |
| New York Giants at Seattle Seahawks | Sunday, December 6th, 2020 at 4:05pm ET | |
| Los Angeles Rams at Arizona Cardinals | Sunday, December 6th, 2020 at 4:05pm ET | |
| Philadelphia Eagles at Green Bay Packers | Sunday, December 6th, 2020 at 4:25pm ET | |
| New England Patriots at Los Angeles Chargers | Sunday, December 6th, 2020 at 4:25pm ET | |
| Denver Broncos at Kansas City Chiefs | Sunday, December 6th, 2020 at 8:20pm ET | |
| Washington Football Team at Pittsburgh Steelers | Monday, December 7th, 2020 at 5:00pm ET | |
| Buffalo Bills at San Francisco 49ers | Monday, December 7th, 2020 at 8:15pm ET | |
| Dallas Cowboys at Baltimore Ravens | Tuesday, December 8th, 2020 at 8:05pm ET |
See the Full Season Schedule
