| Houston Texans at Tennessee Titans | Sunday, October 18th, 2020 at 1:00pm ET | Bye Week: NO, LV, LAC, SEA |
| Detroit Lions at Jacksonville Jaguars | Sunday, October 18th, 2020 at 1:00pm ET | |
| Cincinnati Bengals at Indianapolis Colts | Sunday, October 18th, 2020 at 1:00pm ET | |
| Chicago Bears at Carolina Panthers | Sunday, October 18th, 2020 at 1:00pm ET | |
| Atlanta Falcons at Minnesota Vikings | Sunday, October 18th, 2020 at 1:00pm ET | |
| Washington Football Team at New York Giants | Sunday, October 18th, 2020 at 1:00pm ET | |
| Baltimore Ravens at Philadelphia Eagles | Sunday, October 18th, 2020 at 1:00pm ET | |
| Denver Broncos at New England Patriots | Sunday, October 18th, 2020 at 1:00pm ET | |
| Cleveland Browns at Pittsburgh Steelers | Sunday, October 18th, 2020 at 1:00pm ET | |
| New York Jets at Miami Dolphins | Sunday, October 18th, 2020 at 4:05pm ET | |
| Green Bay Packers at Tampa Bay Buccaneers | Sunday, October 18th, 2020 at 4:25pm ET | |
| Los Angeles Rams at San Francisco 49ers | Sunday, October 18th, 2020 at 8:20pm ET | |
| Kansas City Chiefs at Buffalo Bills | Monday, October 19th, 2020 at 5:00pm ET | |
| Arizona Cardinals at Dallas Cowboys | Monday, October 19th, 2020 at 8:15pm ET |
See the Full Season Schedule
