| New York Giants at Philadelphia Eagles | Thursday, October 22nd, 2020 at 8:20pm ET | Bye Week: BAL, IND, MIA, MIN |
| Green Bay Packers at Houston Texans | Sunday, October 25th, 2020 at 1:00pm ET | |
| Carolina Panthers at New Orleans Saints | Sunday, October 25th, 2020 at 1:00pm ET | |
| Buffalo Bills at New York Jets | Sunday, October 25th, 2020 at 1:00pm ET | |
| Detroit Lions at Atlanta Falcons | Sunday, October 25th, 2020 at 1:00pm ET | |
| Dallas Cowboys at Washington Football Team | Sunday, October 25th, 2020 at 1:00pm ET | |
| Cleveland Browns at Cincinnati Bengals | Sunday, October 25th, 2020 at 1:00pm ET | |
| Pittsburgh Steelers at Tennessee Titans | Sunday, October 25th, 2020 at 1:00pm ET | |
| Seattle Seahawks at Arizona Cardinals | Sunday, October 25th, 2020 at 4:05pm ET | |
| Kansas City Chiefs at Denver Broncos | Sunday, October 25th, 2020 at 4:25pm ET | |
| Jacksonville Jaguars at Los Angeles Chargers | Sunday, October 25th, 2020 at 4:25pm ET | |
| San Francisco 49ers at New England Patriots | Sunday, October 25th, 2020 at 4:25pm ET | |
| Tampa Bay Buccaneers at Las Vegas Raiders | Sunday, October 25th, 2020 at 8:20pm ET | |
| Chicago Bears at Los Angeles Rams | Monday, October 26th, 2020 at 8:15pm ET |
See the Full Season Schedule
