| Dallas Cowboys at Tampa Bay Buccaneers | Thursday, September 9th, 2021 at 8:20pm ET |
Bye Week: none |
| Arizona Cardinals at Tennessee Titans | Sunday, September 12th, 2021 at 1:00pm ET | |
| Jacksonville Jaguars at Houston Texans | Sunday, September 12th, 2021 at 1:00pm ET | |
| Minnesota Vikings at Cincinnati Bengals | Sunday, September 12th, 2021 at 1:00pm ET | |
| Seattle Seahawks at Indianapolis Colts | Sunday, September 12th, 2021 at 1:00pm ET | |
| Pittsburgh Steelers at Buffalo Bills | Sunday, September 12th, 2021 at 1:00pm ET | |
| San Francisco 49ers at Detroit Lions | Sunday, September 12th, 2021 at 1:00pm ET | |
| Los Angeles Chargers at Washington Football Team | Sunday, September 12th, 2021 at 1:00pm ET | |
| New York Jets at Carolina Panthers | Sunday, September 12th, 2021 at 1:00pm ET | |
| Philadelphia Eagles at Atlanta Falcons | Sunday, September 12th, 2021 at 1:00pm ET | |
| Cleveland Browns at Kansas City Chiefs | Sunday, September 12th, 2021 at 4:25pm ET | |
| Green Bay Packers at New Orleans Saints | Sunday, September 12th, 2021 at 4:25pm ET | |
| Denver Broncos at New York Giants | Sunday, September 12th, 2021 at 4:25pm ET | |
| Miami Dolphins at New England Patriots | Sunday, September 12th, 2021 at 4:25pm ET | |
| Chicago Bears at Los Angeles Rams | Sunday, September 12th, 2021 at 8:20pm ET | |
| Baltimore Ravens at Las Vegas Raiders | Monday, September 13th, 2021 at 8:15pm ET |
See the Full Season Schedule
