| Buffalo Bills at Los Angeles Rams | Thursday, September 8th, 2022 at 8:20pm ET |
Bye Week: none |
| New Orleans Saints at Atlanta Falcons | Sunday, September 11th, 2022 at 1:00pm ET | |
| Baltimore Ravens at New York Jets | Sunday, September 11th, 2022 at 1:00pm ET | |
| Pittsburgh Steelers at Cincinnati Bengals | Sunday, September 11th, 2022 at 1:00pm ET | |
| New England Patriots at Miami Dolphins | Sunday, September 11th, 2022 at 1:00pm ET | |
| Jacksonville Jaguars at Washington Commanders | Sunday, September 11th, 2022 at 1:00pm ET | |
| San Francisco 49ers at Chicago Bears | Sunday, September 11th, 2022 at 1:00pm ET | |
| Cleveland Browns at Carolina Panthers | Sunday, September 11th, 2022 at 1:00pm ET | |
| Indianapolis Colts at Houston Texans | Sunday, September 11th, 2022 at 1:00pm ET | |
| Philadelphia Eagles at Detroit Lions | Sunday, September 11th, 2022 at 1:00pm ET | |
| Las Vegas Raiders at Los Angeles Chargers | Sunday, September 11th, 2022 at 4:25pm ET | |
| Green Bay Packers at Minnesota Vikings | Sunday, September 11th, 2022 at 4:25pm ET | |
| New York Giants at Tennessee Titans | Sunday, September 11th, 2022 at 4:25pm ET | |
| Kansas City Chiefs at Arizona Cardinals | Sunday, September 11th, 2022 at 4:25pm ET | |
| Tampa Bay Buccaneers at Dallas Cowboys | Sunday, September 11th, 2022 at 8:20pm ET | |
| Denver Broncos at Seattle Seahawks | Monday, September 12th, 2022 at 8:15pm ET |
See the Full Season Schedule
