| Dallas Cowboys at Philadelphia Eagles | Thursday, September 4th, 2025 at 8:20pm ET |
Bye Week: none |
| Kansas City Chiefs at Los Angeles Chargers | Friday, September 5th, 2025 at 8:00pm ET | |
| Tampa Bay Buccaneers at Atlanta Falcons | Sunday, September 7th, 2025 at 1:00pm ET | |
| Cincinnati Bengals at Cleveland Browns | Sunday, September 7th, 2025 at 1:00pm ET | |
| Miami Dolphins at Indianapolis Colts | Sunday, September 7th, 2025 at 1:00pm ET | |
| Carolina Panthers at Jacksonville Jaguars | Sunday, September 7th, 2025 at 1:00pm ET | |
| Las Vegas Raiders at New England Patriots | Sunday, September 7th, 2025 at 1:00pm ET | |
| Arizona Cardinals at New Orleans Saints | Sunday, September 7th, 2025 at 1:00pm ET | |
| Pittsburgh Steelers at New York Jets | Sunday, September 7th, 2025 at 1:00pm ET | |
| New York Giants at Washington Commanders | Sunday, September 7th, 2025 at 1:00pm ET | |
| Tennessee Titans at Denver Broncos | Sunday, September 7th, 2025 at 4:05pm ET | |
| San Francisco 49ers at Seattle Seahawks | Sunday, September 7th, 2025 at 4:05pm ET | |
| Detroit Lions at Green Bay Packers | Sunday, September 7th, 2025 at 4:25pm ET | |
| Houston Texans at Los Angeles Rams | Sunday, September 7th, 2025 at 4:25pm ET | |
| Baltimore Ravens at Buffalo Bills | Sunday, September 7th, 2025 at 8:20pm ET | |
| Minnesota Vikings at Chicago Bears | Monday, September 8th, 2025 at 8:15pm ET |
See the Full Season Schedule
