| New England Patriots at Atlanta Falcons | Thursday, November 18th, 2021 at 8:20pm ET |
Bye Week: DEN, LAR |
| Houston Texans at Tennessee Titans | Sunday, November 21st, 2021 at 1:00pm ET | |
| San Francisco 49ers at Jacksonville Jaguars | Sunday, November 21st, 2021 at 1:00pm ET | |
| Green Bay Packers at Minnesota Vikings | Sunday, November 21st, 2021 at 1:00pm ET | |
| Indianapolis Colts at Buffalo Bills | Sunday, November 21st, 2021 at 1:00pm ET | |
| Detroit Lions at Cleveland Browns | Sunday, November 21st, 2021 at 1:00pm ET | |
| Washington Football Team at Carolina Panthers | Sunday, November 21st, 2021 at 1:00pm ET | |
| Miami Dolphins at New York Jets | Sunday, November 21st, 2021 at 1:00pm ET | |
| New Orleans Saints at Philadelphia Eagles | Sunday, November 21st, 2021 at 1:00pm ET | |
| Baltimore Ravens at Chicago Bears | Sunday, November 21st, 2021 at 1:00pm ET | |
| Cincinnati Bengals at Las Vegas Raiders | Sunday, November 21st, 2021 at 4:05pm ET | |
| Dallas Cowboys at Kansas City Chiefs | Sunday, November 21st, 2021 at 4:25pm ET | |
| Arizona Cardinals at Seattle Seahawks | Sunday, November 21st, 2021 at 4:25pm ET | |
| Pittsburgh Steelers at Los Angeles Chargers | Sunday, November 21st, 2021 at 8:20pm ET | |
| New York Giants at Tampa Bay Buccaneers | Monday, November 22nd, 2021 at 8:15pm ET |
See the Full Season Schedule
