| Buffalo Bills at Detroit Lions | Thursday, November 24th, 2022 at 12:30pm ET |
Bye Week: none |
| New York Giants at Dallas Cowboys | Thursday, November 24th, 2022 at 4:30pm ET | |
| New England Patriots at Minnesota Vikings | Thursday, November 24th, 2022 at 8:20pm ET | |
| Atlanta Falcons at Washington Commanders | Sunday, November 27th, 2022 at 1:00pm ET | |
| Chicago Bears at New York Jets | Sunday, November 27th, 2022 at 1:00pm ET | |
| Baltimore Ravens at Jacksonville Jaguars | Sunday, November 27th, 2022 at 1:00pm ET | |
| Cincinnati Bengals at Tennessee Titans | Sunday, November 27th, 2022 at 1:00pm ET | |
| Houston Texans at Miami Dolphins | Sunday, November 27th, 2022 at 1:00pm ET | |
| Denver Broncos at Carolina Panthers | Sunday, November 27th, 2022 at 1:00pm ET | |
| Tampa Bay Buccaneers at Cleveland Browns | Sunday, November 27th, 2022 at 1:00pm ET | |
| Los Angeles Chargers at Arizona Cardinals | Sunday, November 27th, 2022 at 4:05pm ET | |
| Las Vegas Raiders at Seattle Seahawks | Sunday, November 27th, 2022 at 4:05pm ET | |
| Los Angeles Rams at Kansas City Chiefs | Sunday, November 27th, 2022 at 4:25pm ET | |
| New Orleans Saints at San Francisco 49ers | Sunday, November 27th, 2022 at 4:25pm ET | |
| Green Bay Packers at Philadelphia Eagles | Sunday, November 27th, 2022 at 8:20pm ET | |
| Pittsburgh Steelers at Indianapolis Colts | Monday, November 28th, 2022 at 8:15pm ET |
See the Full Season Schedule
