| Buffalo Bills at Houston Texans | Thursday, November 20th, 2025 at 8:15pm ET |
Bye Week: DEN, MIA, LAC, WAS |
| Indianapolis Colts at Kansas City Chiefs | Sunday, November 23rd, 2025 at 1:00pm ET | |
| New England Patriots at Cincinnati Bengals | Sunday, November 23rd, 2025 at 1:00pm ET | |
| New York Jets at Baltimore Ravens | Sunday, November 23rd, 2025 at 1:00pm ET | |
| Pittsburgh Steelers at Chicago Bears | Sunday, November 23rd, 2025 at 1:00pm ET | |
| New York Giants at Detroit Lions | Sunday, November 23rd, 2025 at 1:00pm ET | |
| Seattle Seahawks at Tennessee Titans | Sunday, November 23rd, 2025 at 1:00pm ET | |
| Minnesota Vikings at Green Bay Packers | Sunday, November 23rd, 2025 at 1:00pm ET | |
| Cleveland Browns at Las Vegas Raiders | Sunday, November 23rd, 2025 at 4:05pm ET | |
| Jacksonville Jaguars at Arizona Cardinals | Sunday, November 23rd, 2025 at 4:05pm ET | |
| Philadelphia Eagles at Dallas Cowboys | Sunday, November 23rd, 2025 at 4:25pm ET | |
| Atlanta Falcons at New Orleans Saints | Sunday, November 23rd, 2025 at 4:25pm ET | |
| Tampa Bay Buccaneers at Los Angeles Rams | Sunday, November 23rd, 2025 at 8:20pm ET | |
| Carolina Panthers at San Francisco 49ers | Monday, November 24th, 2025 at 8:15pm ET |
See the Full Season Schedule
