| Chicago Bears at Detroit Lions | Thursday, November 25th, 2021 at 12:30pm ET |
Bye Week: ARI, KC |
| Las Vegas Raiders at Dallas Cowboys | Thursday, November 25th, 2021 at 4:30pm ET | |
| Buffalo Bills at New Orleans Saints | Thursday, November 25th, 2021 at 8:20pm ET | |
| Tampa Bay Buccaneers at Indianapolis Colts | Sunday, November 28th, 2021 at 1:00pm ET | |
| Tennessee Titans at New England Patriots | Sunday, November 28th, 2021 at 1:00pm ET | |
| New York Jets at Houston Texans | Sunday, November 28th, 2021 at 1:00pm ET | |
| Atlanta Falcons at Jacksonville Jaguars | Sunday, November 28th, 2021 at 1:00pm ET | |
| Pittsburgh Steelers at Cincinnati Bengals | Sunday, November 28th, 2021 at 1:00pm ET | |
| Carolina Panthers at Miami Dolphins | Sunday, November 28th, 2021 at 1:00pm ET | |
| Philadelphia Eagles at New York Giants | Sunday, November 28th, 2021 at 1:00pm ET | |
| Los Angeles Chargers at Denver Broncos | Sunday, November 28th, 2021 at 4:05pm ET | |
| Minnesota Vikings at San Francisco 49ers | Sunday, November 28th, 2021 at 4:25pm ET | |
| Los Angeles Rams at Green Bay Packers | Sunday, November 28th, 2021 at 4:25pm ET | |
| Cleveland Browns at Baltimore Ravens | Sunday, November 28th, 2021 at 8:20pm ET | |
| Seattle Seahawks at Washington Football Team | Monday, November 29th, 2021 at 8:15pm ET |
See the Full Season Schedule
