| Buffalo Bills at New England Patriots | Thursday, December 1st, 2022 at 8:15pm ET |
Bye Week: ARI, CAR |
| Pittsburgh Steelers at Atlanta Falcons | Sunday, December 4th, 2022 at 1:00pm ET | |
| New York Jets at Minnesota Vikings | Sunday, December 4th, 2022 at 1:00pm ET | |
| Denver Broncos at Baltimore Ravens | Sunday, December 4th, 2022 at 1:00pm ET | |
| Washington Commanders at New York Giants | Sunday, December 4th, 2022 at 1:00pm ET | |
| Jacksonville Jaguars at Detroit Lions | Sunday, December 4th, 2022 at 1:00pm ET | |
| Green Bay Packers at Chicago Bears | Sunday, December 4th, 2022 at 1:00pm ET | |
| Cleveland Browns at Houston Texans | Sunday, December 4th, 2022 at 1:00pm ET | |
| Tennessee Titans at Philadelphia Eagles | Sunday, December 4th, 2022 at 1:00pm ET | |
| Seattle Seahawks at Los Angeles Rams | Sunday, December 4th, 2022 at 4:05pm ET | |
| Miami Dolphins at San Francisco 49ers | Sunday, December 4th, 2022 at 4:05pm ET | |
| Kansas City Chiefs at Cincinnati Bengals | Sunday, December 4th, 2022 at 4:25pm ET | |
| Los Angeles Chargers at Las Vegas Raiders | Sunday, December 4th, 2022 at 4:25pm ET | |
| Indianapolis Colts at Dallas Cowboys | Sunday, December 4th, 2022 at 8:20pm ET | |
| New Orleans Saints at Tampa Bay Buccaneers | Monday, December 5th, 2022 at 8:15pm ET |
See the Full Season Schedule
