| Dallas Cowboys at New Orleans Saints | Thursday, December 2nd, 2021 at 8:20pm ET |
Bye Week: CAR, CLE, GB, TEN |
| Tampa Bay Buccaneers at Atlanta Falcons | Sunday, December 5th, 2021 at 1:00pm ET | |
| Arizona Cardinals at Chicago Bears | Sunday, December 5th, 2021 at 1:00pm ET | |
| Indianapolis Colts at Houston Texans | Sunday, December 5th, 2021 at 1:00pm ET | |
| Los Angeles Chargers at Cincinnati Bengals | Sunday, December 5th, 2021 at 1:00pm ET | |
| Minnesota Vikings at Detroit Lions | Sunday, December 5th, 2021 at 1:00pm ET | |
| Philadelphia Eagles at New York Jets | Sunday, December 5th, 2021 at 1:00pm ET | |
| Denver Broncos at Kansas City Chiefs | Sunday, December 5th, 2021 at 1:00pm ET | |
| New York Giants at Miami Dolphins | Sunday, December 5th, 2021 at 1:00pm ET | |
| Washington Football Team at Las Vegas Raiders | Sunday, December 5th, 2021 at 4:05pm ET | |
| Jacksonville Jaguars at Los Angeles Rams | Sunday, December 5th, 2021 at 4:25pm ET | |
| Baltimore Ravens at Pittsburgh Steelers | Sunday, December 5th, 2021 at 4:25pm ET | |
| San Francisco 49ers at Seattle Seahawks | Sunday, December 5th, 2021 at 8:20pm ET | |
| New England Patriots at Buffalo Bills | Monday, December 6th, 2021 at 8:15pm ET |
See the Full Season Schedule
