| Pittsburgh Steelers at Minnesota Vikings | Thursday, December 9th, 2021 at 8:20pm ET |
Bye Week: IND, MIA, NE, PHI |
| Dallas Cowboys at Washington Football Team | Sunday, December 12th, 2021 at 1:00pm ET | |
| Jacksonville Jaguars at Tennessee Titans | Sunday, December 12th, 2021 at 1:00pm ET | |
| Seattle Seahawks at Houston Texans | Sunday, December 12th, 2021 at 1:00pm ET | |
| San Francisco 49ers at Cincinnati Bengals | Sunday, December 12th, 2021 at 1:00pm ET | |
| Atlanta Falcons at Carolina Panthers | Sunday, December 12th, 2021 at 1:00pm ET | |
| New Orleans Saints at New York Jets | Sunday, December 12th, 2021 at 1:00pm ET | |
| Las Vegas Raiders at Kansas City Chiefs | Sunday, December 12th, 2021 at 1:00pm ET | |
| Baltimore Ravens at Cleveland Browns | Sunday, December 12th, 2021 at 1:00pm ET | |
| Detroit Lions at Denver Broncos | Sunday, December 12th, 2021 at 4:05pm ET | |
| New York Giants at Los Angeles Chargers | Sunday, December 12th, 2021 at 4:05pm ET | |
| Buffalo Bills at Tampa Bay Buccaneers | Sunday, December 12th, 2021 at 4:25pm ET | |
| Chicago Bears at Green Bay Packers | Sunday, December 12th, 2021 at 8:20pm ET | |
| Los Angeles Rams at Arizona Cardinals | Monday, December 13th, 2021 at 8:15pm ET |
See the Full Season Schedule
