| San Francisco 49ers at Seattle Seahawks | Thursday, December 15th, 2022 at 8:15pm ET |
Bye Week: none |
| Miami Dolphins at Buffalo Bills | Sunday, December 18th, 2022 at 1:00pm ET | |
| Atlanta Falcons at New Orleans Saints | Sunday, December 18th, 2022 at 1:00pm ET | |
| Detroit Lions at New York Jets | Sunday, December 18th, 2022 at 1:00pm ET | |
| Baltimore Ravens at Cleveland Browns | Sunday, December 18th, 2022 at 1:00pm ET | |
| Pittsburgh Steelers at Carolina Panthers | Sunday, December 18th, 2022 at 1:00pm ET | |
| New York Giants at Washington Commanders | Sunday, December 18th, 2022 at 1:00pm ET | |
| Dallas Cowboys at Jacksonville Jaguars | Sunday, December 18th, 2022 at 1:00pm ET | |
| Philadelphia Eagles at Chicago Bears | Sunday, December 18th, 2022 at 1:00pm ET | |
| Kansas City Chiefs at Houston Texans | Sunday, December 18th, 2022 at 1:00pm ET | |
| Indianapolis Colts at Minnesota Vikings | Sunday, December 18th, 2022 at 1:00pm ET | |
| Arizona Cardinals at Denver Broncos | Sunday, December 18th, 2022 at 4:05pm ET | |
| Cincinnati Bengals at Tampa Bay Buccaneers | Sunday, December 18th, 2022 at 4:25pm ET | |
| Tennessee Titans at Los Angeles Chargers | Sunday, December 18th, 2022 at 4:25pm ET | |
| New England Patriots at Las Vegas Raiders | Sunday, December 18th, 2022 at 8:20pm ET | |
| Los Angeles Rams at Green Bay Packers | Monday, December 19th, 2022 at 8:15pm ET |
See the Full Season Schedule
