| Kansas City Chiefs at Los Angeles Chargers | Thursday, December 16th, 2021 at 8:20pm ET |
Bye Week: none |
| Dallas Cowboys at New York Giants | Sunday, December 19th, 2021 at 1:00pm ET | |
| Tennessee Titans at Pittsburgh Steelers | Sunday, December 19th, 2021 at 1:00pm ET | |
| Arizona Cardinals at Detroit Lions | Sunday, December 19th, 2021 at 1:00pm ET | |
| Houston Texans at Jacksonville Jaguars | Sunday, December 19th, 2021 at 1:00pm ET | |
| New England Patriots at Indianapolis Colts | Sunday, December 19th, 2021 at 1:00pm ET | |
| Carolina Panthers at Buffalo Bills | Sunday, December 19th, 2021 at 1:00pm ET | |
| Washington Football Team at Philadelphia Eagles | Sunday, December 19th, 2021 at 1:00pm ET | |
| New York Jets at Miami Dolphins | Sunday, December 19th, 2021 at 1:00pm ET | |
| Las Vegas Raiders at Cleveland Browns | Sunday, December 19th, 2021 at 1:00pm ET | |
| Green Bay Packers at Baltimore Ravens | Sunday, December 19th, 2021 at 1:00pm ET | |
| Cincinnati Bengals at Denver Broncos | Sunday, December 19th, 2021 at 4:05pm ET | |
| Atlanta Falcons at San Francisco 49ers | Sunday, December 19th, 2021 at 4:05pm ET | |
| Seattle Seahawks at Los Angeles Rams | Sunday, December 19th, 2021 at 4:25pm ET | |
| New Orleans Saints at Tampa Bay Buccaneers | Sunday, December 19th, 2021 at 8:20pm ET | |
| Minnesota Vikings at Chicago Bears | Monday, December 20th, 2021 at 8:15pm ET |
See the Full Season Schedule
