| Los Angeles Chargers at Las Vegas Raiders | Thursday, December 17th, 2020 at 8:20pm ET | Bye Week: none |
| Buffalo Bills at Denver Broncos | Saturday, December 19th, 2020 at 4:30pm ET | |
| Carolina Panthers at Green Bay Packers | Saturday, December 19th, 2020 at 8:15pm ET | |
| Houston Texans at Indianapolis Colts | Sunday, December 20th, 2020 at 1:00pm ET | |
| Jacksonville Jaguars at Baltimore Ravens | Sunday, December 20th, 2020 at 1:00pm ET | |
| Tampa Bay Buccaneers at Atlanta Falcons | Sunday, December 20th, 2020 at 1:00pm ET | |
| Seattle Seahawks at Washington Football Team | Sunday, December 20th, 2020 at 1:00pm ET | |
| New England Patriots at Miami Dolphins | Sunday, December 20th, 2020 at 1:00pm ET | |
| Chicago Bears at Minnesota Vikings | Sunday, December 20th, 2020 at 1:00pm ET | |
| Detroit Lions at Tennessee Titans | Sunday, December 20th, 2020 at 1:00pm ET | |
| San Francisco 49ers at Dallas Cowboys | Sunday, December 20th, 2020 at 1:00pm ET | |
| New York Jets at Los Angeles Rams | Sunday, December 20th, 2020 at 4:05pm ET | |
| Philadelphia Eagles at Arizona Cardinals | Sunday, December 20th, 2020 at 4:05pm ET | |
| Kansas City Chiefs at New Orleans Saints | Sunday, December 20th, 2020 at 4:25pm ET | |
| Cleveland Browns at New York Giants | Sunday, December 20th, 2020 at 8:20pm ET | |
| Pittsburgh Steelers at Cincinnati Bengals | Monday, December 21st, 2020 at 8:15pm ET |
See the Full Season Schedule
