| Minnesota Vikings at New Orleans Saints | Friday, December 25th, 2020 at 4:30pm ET | Bye Week: none |
| Tampa Bay Buccaneers at Detroit Lions | Saturday, December 26th, 2020 at 1:00pm ET | |
| San Francisco 49ers at Arizona Cardinals | Saturday, December 26th, 2020 at 4:30pm ET | |
| Miami Dolphins at Las Vegas Raiders | Saturday, December 26th, 2020 at 8:15pm ET | |
| Atlanta Falcons at Kansas City Chiefs | Sunday, December 27th, 2020 at 1:00pm ET | |
| Cincinnati Bengals at Houston Texans | Sunday, December 27th, 2020 at 1:00pm ET | |
| Chicago Bears at Jacksonville Jaguars | Sunday, December 27th, 2020 at 1:00pm ET | |
| Indianapolis Colts at Pittsburgh Steelers | Sunday, December 27th, 2020 at 1:00pm ET | |
| Cleveland Browns at New York Jets | Sunday, December 27th, 2020 at 1:00pm ET | |
| New York Giants at Baltimore Ravens | Sunday, December 27th, 2020 at 1:00pm ET | |
| Carolina Panthers at Washington Football Team | Sunday, December 27th, 2020 at 4:05pm ET | |
| Denver Broncos at Los Angeles Chargers | Sunday, December 27th, 2020 at 4:05pm ET | |
| Los Angeles Rams at Seattle Seahawks | Sunday, December 27th, 2020 at 4:25pm ET | |
| Philadelphia Eagles at Dallas Cowboys | Sunday, December 27th, 2020 at 4:25pm ET | |
| Tennessee Titans at Green Bay Packers | Sunday, December 27th, 2020 at 8:20pm ET | |
| Buffalo Bills at New England Patriots | Monday, December 28th, 2020 at 8:15pm ET |
See the Full Season Schedule
