| San Francisco 49ers at Tennessee Titans | Thursday, December 23rd, 2021 at 8:20pm ET |
Bye Week: none |
| Cleveland Browns at Green Bay Packers | Saturday, December 25th, 2021 at 4:30pm ET | |
| Indianapolis Colts at Arizona Cardinals | Saturday, December 25th, 2021 at 8:15pm ET | |
| Tampa Bay Buccaneers at Carolina Panthers | Sunday, December 26th, 2021 at 1:00pm ET | |
| Los Angeles Chargers at Houston Texans | Sunday, December 26th, 2021 at 1:00pm ET | |
| Jacksonville Jaguars at New York Jets | Sunday, December 26th, 2021 at 1:00pm ET | |
| Baltimore Ravens at Cincinnati Bengals | Sunday, December 26th, 2021 at 1:00pm ET | |
| Los Angeles Rams at Minnesota Vikings | Sunday, December 26th, 2021 at 1:00pm ET | |
| Buffalo Bills at New England Patriots | Sunday, December 26th, 2021 at 1:00pm ET | |
| Detroit Lions at Atlanta Falcons | Sunday, December 26th, 2021 at 1:00pm ET | |
| New York Giants at Philadelphia Eagles | Sunday, December 26th, 2021 at 1:00pm ET | |
| Chicago Bears at Seattle Seahawks | Sunday, December 26th, 2021 at 4:05pm ET | |
| Pittsburgh Steelers at Kansas City Chiefs | Sunday, December 26th, 2021 at 4:25pm ET | |
| Denver Broncos at Las Vegas Raiders | Sunday, December 26th, 2021 at 4:25pm ET | |
| Washington Football Team at Dallas Cowboys | Sunday, December 26th, 2021 at 8:20pm ET | |
| Miami Dolphins at New Orleans Saints | Monday, December 27th, 2021 at 8:15pm ET |
See the Full Season Schedule
