| Tampa Bay Buccaneers at New York Jets | Sunday, January 2nd, 2022 at 1:00pm ET |
Bye Week: none |
| Arizona Cardinals at Dallas Cowboys | Sunday, January 2nd, 2022 at 1:00pm ET | |
| Miami Dolphins at Tennessee Titans | Sunday, January 2nd, 2022 at 1:00pm ET | |
| Jacksonville Jaguars at New England Patriots | Sunday, January 2nd, 2022 at 1:00pm ET | |
| Kansas City Chiefs at Cincinnati Bengals | Sunday, January 2nd, 2022 at 1:00pm ET | |
| Las Vegas Raiders at Indianapolis Colts | Sunday, January 2nd, 2022 at 1:00pm ET | |
| Atlanta Falcons at Buffalo Bills | Sunday, January 2nd, 2022 at 1:00pm ET | |
| Philadelphia Eagles at Washington Football Team | Sunday, January 2nd, 2022 at 1:00pm ET | |
| Carolina Panthers at New Orleans Saints | Sunday, January 2nd, 2022 at 1:00pm ET | |
| New York Giants at Chicago Bears | Sunday, January 2nd, 2022 at 1:00pm ET | |
| Houston Texans at San Francisco 49ers | Sunday, January 2nd, 2022 at 4:05pm ET | |
| Denver Broncos at Los Angeles Chargers | Sunday, January 2nd, 2022 at 4:05pm ET | |
| Detroit Lions at Seattle Seahawks | Sunday, January 2nd, 2022 at 4:25pm ET | |
| Los Angeles Rams at Baltimore Ravens | Sunday, January 2nd, 2022 at 4:25pm ET | |
| Minnesota Vikings at Green Bay Packers | Sunday, January 2nd, 2022 at 8:20pm ET | |
| Cleveland Browns at Pittsburgh Steelers | Monday, January 3rd, 2022 at 8:15pm ET |
See the Full Season Schedule
