| New York Jets at New England Patriots | Sunday, January 3rd, 2021 at 1:00pm ET | Bye Week: none |
| Miami Dolphins at Buffalo Bills | Sunday, January 3rd, 2021 at 1:00pm ET | |
| Atlanta Falcons at Tampa Bay Buccaneers | Sunday, January 3rd, 2021 at 1:00pm ET | |
| Baltimore Ravens at Cincinnati Bengals | Sunday, January 3rd, 2021 at 1:00pm ET | |
| Pittsburgh Steelers at Cleveland Browns | Sunday, January 3rd, 2021 at 1:00pm ET | |
| Minnesota Vikings at Detroit Lions | Sunday, January 3rd, 2021 at 1:00pm ET | |
| Dallas Cowboys at New York Giants | Sunday, January 3rd, 2021 at 1:00pm ET | |
| Los Angeles Chargers at Kansas City Chiefs | Sunday, January 3rd, 2021 at 4:25pm ET | |
| Tennessee Titans at Houston Texans | Sunday, January 3rd, 2021 at 4:25pm ET | |
| Jacksonville Jaguars at Indianapolis Colts | Sunday, January 3rd, 2021 at 4:25pm ET | |
| New Orleans Saints at Carolina Panthers | Sunday, January 3rd, 2021 at 4:25pm ET | |
| Las Vegas Raiders at Denver Broncos | Sunday, January 3rd, 2021 at 4:25pm ET | |
| Seattle Seahawks at San Francisco 49ers | Sunday, January 3rd, 2021 at 4:25pm ET | |
| Green Bay Packers at Chicago Bears | Sunday, January 3rd, 2021 at 4:25pm ET | |
| Arizona Cardinals at Los Angeles Rams | Sunday, January 3rd, 2021 at 4:25pm ET | |
| Washington Football Team at Philadelphia Eagles | Sunday, January 3rd, 2021 at 8:20pm ET |
See the Full Season Schedule
