| New York Giants at Washington Football Team | Thursday, September 16th, 2021 at 8:20pm ET |
Bye Week: none |
| Houston Texans at Cleveland Browns | Sunday, September 19th, 2021 at 1:00pm ET | |
| Denver Broncos at Jacksonville Jaguars | Sunday, September 19th, 2021 at 1:00pm ET | |
| Cincinnati Bengals at Chicago Bears | Sunday, September 19th, 2021 at 1:00pm ET | |
| Los Angeles Rams at Indianapolis Colts | Sunday, September 19th, 2021 at 1:00pm ET | |
| Buffalo Bills at Miami Dolphins | Sunday, September 19th, 2021 at 1:00pm ET | |
| Las Vegas Raiders at Pittsburgh Steelers | Sunday, September 19th, 2021 at 1:00pm ET | |
| San Francisco 49ers at Philadelphia Eagles | Sunday, September 19th, 2021 at 1:00pm ET | |
| New Orleans Saints at Carolina Panthers | Sunday, September 19th, 2021 at 1:00pm ET | |
| New England Patriots at New York Jets | Sunday, September 19th, 2021 at 1:00pm ET | |
| Atlanta Falcons at Tampa Bay Buccaneers | Sunday, September 19th, 2021 at 4:05pm ET | |
| Minnesota Vikings at Arizona Cardinals | Sunday, September 19th, 2021 at 4:05pm ET | |
| Dallas Cowboys at Los Angeles Chargers | Sunday, September 19th, 2021 at 4:25pm ET | |
| Tennessee Titans at Seattle Seahawks | Sunday, September 19th, 2021 at 4:25pm ET | |
| Kansas City Chiefs at Baltimore Ravens | Sunday, September 19th, 2021 at 8:20pm ET | |
| Detroit Lions at Green Bay Packers | Monday, September 20th, 2021 at 8:15pm ET |
See the Full Season Schedule
