| Washington Commanders at Green Bay Packers | Thursday, September 11th, 2025 at 8:15pm ET |
Bye Week: none |
| New York Giants at Dallas Cowboys | Sunday, September 14th, 2025 at 1:00pm ET | |
| Cleveland Browns at Baltimore Ravens | Sunday, September 14th, 2025 at 1:00pm ET | |
| Jacksonville Jaguars at Cincinnati Bengals | Sunday, September 14th, 2025 at 1:00pm ET | |
| New England Patriots at Miami Dolphins | Sunday, September 14th, 2025 at 1:00pm ET | |
| San Francisco 49ers at New Orleans Saints | Sunday, September 14th, 2025 at 1:00pm ET | |
| Buffalo Bills at New York Jets | Sunday, September 14th, 2025 at 1:00pm ET | |
| Seattle Seahawks at Pittsburgh Steelers | Sunday, September 14th, 2025 at 1:00pm ET | |
| Los Angeles Rams at Tennessee Titans | Sunday, September 14th, 2025 at 1:00pm ET | |
| Chicago Bears at Detroit Lions | Sunday, September 14th, 2025 at 1:00pm ET | |
| Denver Broncos at Indianapolis Colts | Sunday, September 14th, 2025 at 4:05pm ET | |
| Carolina Panthers at Arizona Cardinals | Sunday, September 14th, 2025 at 4:05pm ET | |
| Philadelphia Eagles at Kansas City Chiefs | Sunday, September 14th, 2025 at 4:25pm ET | |
| Atlanta Falcons at Minnesota Vikings | Sunday, September 14th, 2025 at 8:20pm ET | |
| Tampa Bay Buccaneers at Houston Texans | Monday, September 15th, 2025 at 7:00pm ET | |
| Los Angeles Chargers at Las Vegas Raiders | Monday, September 15th, 2025 at 10:00pm ET |
See the Full Season Schedule
