| Los Angeles Chargers at Kansas City Chiefs | Thursday, September 15th, 2022 at 8:15pm ET |
Bye Week: none |
| Tampa Bay Buccaneers at New Orleans Saints | Sunday, September 18th, 2022 at 1:00pm ET | |
| New York Jets at Cleveland Browns | Sunday, September 18th, 2022 at 1:00pm ET | |
| Miami Dolphins at Baltimore Ravens | Sunday, September 18th, 2022 at 1:00pm ET | |
| New England Patriots at Pittsburgh Steelers | Sunday, September 18th, 2022 at 1:00pm ET | |
| Washington Commanders at Detroit Lions | Sunday, September 18th, 2022 at 1:00pm ET | |
| Indianapolis Colts at Jacksonville Jaguars | Sunday, September 18th, 2022 at 1:00pm ET | |
| Carolina Panthers at New York Giants | Sunday, September 18th, 2022 at 1:00pm ET | |
| Atlanta Falcons at Los Angeles Rams | Sunday, September 18th, 2022 at 4:05pm ET | |
| Seattle Seahawks at San Francisco 49ers | Sunday, September 18th, 2022 at 4:05pm ET | |
| Cincinnati Bengals at Dallas Cowboys | Sunday, September 18th, 2022 at 4:25pm ET | |
| Houston Texans at Denver Broncos | Sunday, September 18th, 2022 at 4:25pm ET | |
| Arizona Cardinals at Las Vegas Raiders | Sunday, September 18th, 2022 at 4:25pm ET | |
| Chicago Bears at Green Bay Packers | Sunday, September 18th, 2022 at 8:20pm ET | |
| Tennessee Titans at Buffalo Bills | Monday, September 19th, 2022 at 7:15pm ET | |
| Minnesota Vikings at Philadelphia Eagles | Monday, September 19th, 2022 at 8:30pm ET |
See the Full Season Schedule
