| Miami Dolphins at Buffalo Bills | Thursday, September 18th, 2025 at 8:15pm ET |
Bye Week: none |
| Los Angeles Rams at Philadelphia Eagles | Sunday, September 21st, 2025 at 1:00pm ET | |
| Atlanta Falcons at Carolina Panthers | Sunday, September 21st, 2025 at 1:00pm ET | |
| New York Jets at Tampa Bay Buccaneers | Sunday, September 21st, 2025 at 1:00pm ET | |
| Green Bay Packers at Cleveland Browns | Sunday, September 21st, 2025 at 1:00pm ET | |
| Cincinnati Bengals at Minnesota Vikings | Sunday, September 21st, 2025 at 1:00pm ET | |
| Indianapolis Colts at Tennessee Titans | Sunday, September 21st, 2025 at 1:00pm ET | |
| Houston Texans at Jacksonville Jaguars | Sunday, September 21st, 2025 at 1:00pm ET | |
| Pittsburgh Steelers at New England Patriots | Sunday, September 21st, 2025 at 1:00pm ET | |
| Las Vegas Raiders at Washington Commanders | Sunday, September 21st, 2025 at 1:00pm ET | |
| Denver Broncos at Los Angeles Chargers | Sunday, September 21st, 2025 at 4:05pm ET | |
| New Orleans Saints at Seattle Seahawks | Sunday, September 21st, 2025 at 4:05pm ET | |
| Dallas Cowboys at Chicago Bears | Sunday, September 21st, 2025 at 4:25pm ET | |
| Arizona Cardinals at San Francisco 49ers | Sunday, September 21st, 2025 at 4:25pm ET | |
| Kansas City Chiefs at New York Giants | Sunday, September 21st, 2025 at 8:20pm ET | |
| Detroit Lions at Baltimore Ravens | Monday, September 22nd, 2025 at 8:15pm ET |
See the Full Season Schedule
