| Pittsburgh Steelers at Cleveland Browns | Thursday, September 22nd, 2022 at 8:15pm ET |
Bye Week: none |
| Buffalo Bills at Miami Dolphins | Sunday, September 25th, 2022 at 1:00pm ET | |
| New Orleans Saints at Carolina Panthers | Sunday, September 25th, 2022 at 1:00pm ET | |
| Cincinnati Bengals at New York Jets | Sunday, September 25th, 2022 at 1:00pm ET | |
| Baltimore Ravens at New England Patriots | Sunday, September 25th, 2022 at 1:00pm ET | |
| Philadelphia Eagles at Washington Commanders | Sunday, September 25th, 2022 at 1:00pm ET | |
| Houston Texans at Chicago Bears | Sunday, September 25th, 2022 at 1:00pm ET | |
| Kansas City Chiefs at Indianapolis Colts | Sunday, September 25th, 2022 at 1:00pm ET | |
| Detroit Lions at Minnesota Vikings | Sunday, September 25th, 2022 at 1:00pm ET | |
| Las Vegas Raiders at Tennessee Titans | Sunday, September 25th, 2022 at 1:00pm ET | |
| Jacksonville Jaguars at Los Angeles Chargers | Sunday, September 25th, 2022 at 4:05pm ET | |
| Los Angeles Rams at Arizona Cardinals | Sunday, September 25th, 2022 at 4:25pm ET | |
| Atlanta Falcons at Seattle Seahawks | Sunday, September 25th, 2022 at 4:25pm ET | |
| Green Bay Packers at Tampa Bay Buccaneers | Sunday, September 25th, 2022 at 4:25pm ET | |
| San Francisco 49ers at Denver Broncos | Sunday, September 25th, 2022 at 8:20pm ET | |
| Dallas Cowboys at New York Giants | Monday, September 26th, 2022 at 8:15pm ET |
See the Full Season Schedule
