| Carolina Panthers at Houston Texans | Thursday, September 23rd, 2021 at 8:20pm ET |
Bye Week: none |
| Indianapolis Colts at Tennessee Titans | Sunday, September 26th, 2021 at 1:00pm ET | |
| Arizona Cardinals at Jacksonville Jaguars | Sunday, September 26th, 2021 at 1:00pm ET | |
| Cincinnati Bengals at Pittsburgh Steelers | Sunday, September 26th, 2021 at 1:00pm ET | |
| Washington Football Team at Buffalo Bills | Sunday, September 26th, 2021 at 1:00pm ET | |
| Baltimore Ravens at Detroit Lions | Sunday, September 26th, 2021 at 1:00pm ET | |
| Los Angeles Chargers at Kansas City Chiefs | Sunday, September 26th, 2021 at 1:00pm ET | |
| Atlanta Falcons at New York Giants | Sunday, September 26th, 2021 at 1:00pm ET | |
| Chicago Bears at Cleveland Browns | Sunday, September 26th, 2021 at 1:00pm ET | |
| New Orleans Saints at New England Patriots | Sunday, September 26th, 2021 at 1:00pm ET | |
| New York Jets at Denver Broncos | Sunday, September 26th, 2021 at 4:05pm ET | |
| Miami Dolphins at Las Vegas Raiders | Sunday, September 26th, 2021 at 4:05pm ET | |
| Tampa Bay Buccaneers at Los Angeles Rams | Sunday, September 26th, 2021 at 4:25pm ET | |
| Seattle Seahawks at Minnesota Vikings | Sunday, September 26th, 2021 at 4:25pm ET | |
| Green Bay Packers at San Francisco 49ers | Sunday, September 26th, 2021 at 8:20pm ET | |
| Philadelphia Eagles at Dallas Cowboys | Monday, September 27th, 2021 at 8:15pm ET |
See the Full Season Schedule
