| Seattle Seahawks at Arizona Cardinals | Thursday, September 25th, 2025 at 8:15pm ET |
Bye Week: none |
| Minnesota Vikings at Pittsburgh Steelers | Sunday, September 28th, 2025 at 9:30am ET | |
| Philadelphia Eagles at Tampa Bay Buccaneers | Sunday, September 28th, 2025 at 1:00pm ET | |
| Los Angeles Chargers at New York Giants | Sunday, September 28th, 2025 at 1:00pm ET | |
| Washington Commanders at Atlanta Falcons | Sunday, September 28th, 2025 at 1:00pm ET | |
| Cleveland Browns at Detroit Lions | Sunday, September 28th, 2025 at 1:00pm ET | |
| Carolina Panthers at New England Patriots | Sunday, September 28th, 2025 at 1:00pm ET | |
| New Orleans Saints at Buffalo Bills | Sunday, September 28th, 2025 at 1:00pm ET | |
| Tennessee Titans at Houston Texans | Sunday, September 28th, 2025 at 1:00pm ET | |
| Indianapolis Colts at Los Angeles Rams | Sunday, September 28th, 2025 at 4:05pm ET | |
| Jacksonville Jaguars at San Francisco 49ers | Sunday, September 28th, 2025 at 4:05pm ET | |
| Baltimore Ravens at Kansas City Chiefs | Sunday, September 28th, 2025 at 4:25pm ET | |
| Chicago Bears at Las Vegas Raiders | Sunday, September 28th, 2025 at 4:25pm ET | |
| Green Bay Packers at Dallas Cowboys | Sunday, September 28th, 2025 at 8:20pm ET | |
| New York Jets at Miami Dolphins | Monday, September 29th, 2025 at 7:15pm ET | |
| Cincinnati Bengals at Denver Broncos | Monday, September 29th, 2025 at 8:15pm ET |
See the Full Season Schedule
