| Indianapolis Colts at Denver Broncos | Thursday, October 6th, 2022 at 8:15pm ET |
Bye Week: none |
| New York Giants at Green Bay Packers | Sunday, October 9th, 2022 at 9:30am ET | |
| Pittsburgh Steelers at Buffalo Bills | Sunday, October 9th, 2022 at 1:00pm ET | |
| Atlanta Falcons at Tampa Bay Buccaneers | Sunday, October 9th, 2022 at 1:00pm ET | |
| Seattle Seahawks at New Orleans Saints | Sunday, October 9th, 2022 at 1:00pm ET | |
| Miami Dolphins at New York Jets | Sunday, October 9th, 2022 at 1:00pm ET | |
| Detroit Lions at New England Patriots | Sunday, October 9th, 2022 at 1:00pm ET | |
| Tennessee Titans at Washington Commanders | Sunday, October 9th, 2022 at 1:00pm ET | |
| Houston Texans at Jacksonville Jaguars | Sunday, October 9th, 2022 at 1:00pm ET | |
| Chicago Bears at Minnesota Vikings | Sunday, October 9th, 2022 at 1:00pm ET | |
| Los Angeles Chargers at Cleveland Browns | Sunday, October 9th, 2022 at 1:00pm ET | |
| San Francisco 49ers at Carolina Panthers | Sunday, October 9th, 2022 at 4:05pm ET | |
| Dallas Cowboys at Los Angeles Rams | Sunday, October 9th, 2022 at 4:25pm ET | |
| Philadelphia Eagles at Arizona Cardinals | Sunday, October 9th, 2022 at 4:25pm ET | |
| Cincinnati Bengals at Baltimore Ravens | Sunday, October 9th, 2022 at 8:20pm ET | |
| Las Vegas Raiders at Kansas City Chiefs | Monday, October 10th, 2022 at 8:15pm ET |
See the Full Season Schedule
