| Los Angeles Rams at Seattle Seahawks | Thursday, October 7th, 2021 at 8:20pm ET |
Bye Week: none |
| New York Jets at Atlanta Falcons | Sunday, October 10th, 2021 at 9:30am ET | |
| Miami Dolphins at Tampa Bay Buccaneers | Sunday, October 10th, 2021 at 1:00pm ET | |
| Tennessee Titans at Jacksonville Jaguars | Sunday, October 10th, 2021 at 1:00pm ET | |
| New England Patriots at Houston Texans | Sunday, October 10th, 2021 at 1:00pm ET | |
| Green Bay Packers at Cincinnati Bengals | Sunday, October 10th, 2021 at 1:00pm ET | |
| Detroit Lions at Minnesota Vikings | Sunday, October 10th, 2021 at 1:00pm ET | |
| Denver Broncos at Pittsburgh Steelers | Sunday, October 10th, 2021 at 1:00pm ET | |
| New Orleans Saints at Washington Football Team | Sunday, October 10th, 2021 at 1:00pm ET | |
| Philadelphia Eagles at Carolina Panthers | Sunday, October 10th, 2021 at 1:00pm ET | |
| Cleveland Browns at Los Angeles Chargers | Sunday, October 10th, 2021 at 4:05pm ET | |
| Chicago Bears at Las Vegas Raiders | Sunday, October 10th, 2021 at 4:05pm ET | |
| New York Giants at Dallas Cowboys | Sunday, October 10th, 2021 at 4:25pm ET | |
| San Francisco 49ers at Arizona Cardinals | Sunday, October 10th, 2021 at 4:25pm ET | |
| Buffalo Bills at Kansas City Chiefs | Sunday, October 10th, 2021 at 8:20pm ET | |
| Indianapolis Colts at Baltimore Ravens | Monday, October 11th, 2021 at 8:15pm ET |
See the Full Season Schedule
