| Indianapolis Colts at New England Patriots | Thursday, October 4th, 2018 at 8:20pm ET | Bye Week: CHI, TB |
| Atlanta Falcons at Pittsburgh Steelers | Sunday, October 7th, 2018 at 1:00pm ET | |
| Miami Dolphins at Cincinnati Bengals | Sunday, October 7th, 2018 at 1:00pm ET | |
| Tennessee Titans at Buffalo Bills | Sunday, October 7th, 2018 at 1:00pm ET | |
| New York Giants at Carolina Panthers | Sunday, October 7th, 2018 at 1:00pm ET | |
| Jacksonville Jaguars at Kansas City Chiefs | Sunday, October 7th, 2018 at 1:00pm ET | |
| Baltimore Ravens at Cleveland Browns | Sunday, October 7th, 2018 at 1:00pm ET | |
| Denver Broncos at New York Jets | Sunday, October 7th, 2018 at 1:00pm ET | |
| Green Bay Packers at Detroit Lions | Sunday, October 7th, 2018 at 1:00pm ET | |
| Oakland Raiders at Los Angeles Chargers | Sunday, October 7th, 2018 at 4:05pm ET | |
| Minnesota Vikings at Philadelphia Eagles | Sunday, October 7th, 2018 at 4:25pm ET | |
| Arizona Cardinals at San Francisco 49ers | Sunday, October 7th, 2018 at 4:25pm ET | |
| Los Angeles Rams at Seattle Seahawks | Sunday, October 7th, 2018 at 4:25pm ET | |
| Dallas Cowboys at Houston Texans | Sunday, October 7th, 2018 at 8:20pm ET | |
| Washington Redskins at New Orleans Saints | Monday, October 8th, 2018 at 8:15pm ET |
See the Full Season Schedule
Fantasy Games
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| Todd Gurley (LAR) | RB | |
| Le'Veon Bell (PIT) | RB | |
| Ezekiel Elliott (DAL) | RB | |
| David Johnson (ARI) | RB | |
| Antonio Brown (PIT) | WR | |
| DeAndre Hopkins (HOU) | WR | |
| Alvin Kamara (NO) | RB | |
| Saquon Barkley (NYG) | RB | |
| Odell Beckham Jr. (NYG) | WR | |
| Kareem Hunt (KC) | RB | |
| View All Rankings |
| Julio Jones (ATL) | WR | |
| Leonard Fournette (JAC) | RB | |
| Melvin Gordon (LAC) | RB | |
| Michael Thomas (NO) | WR | |
| Dalvin Cook (MIN) | RB | |
| Keenan Allen (LAC) | WR | |
| A.J. Green (CIN) | WR | |
| Davante Adams (GB) | WR | |
| Devonta Freeman (ATL) | RB | |
| Mike Evans (TB) | WR |
| LeSean McCoy (BUF) | RB | |
| Jordan Howard (CHI) | RB | |
| Rob Gronkowski (NE) | TE | |
| Doug Baldwin (SEA) | WR | |
| Jerick McKinnon (SF) | RB | |
| Christian McCaffrey (CAR) | RB | |
| Tyreek Hill (KC) | WR | |
| Adam Thielen (MIN) | WR | |
| Joe Mixon (CIN) | RB | |
| Travis Kelce (KC) | TE |
| Mike Trout (LAA) | CF | |
| Mookie Betts (BOS) | RF | |
| Jose Altuve (HOU) | 2B | |
| Nolan Arenado (COL) | 3B | |
| Max Scherzer (WSH) | SP | |
| Bryce Harper (WSH) | RF | |
| Manny Machado (BAL) | 3B | |
| Freddie Freeman (ATL) | 1B,3B | |
| Corey Kluber (CLE) | SP | |
| Jose Ramirez (CLE) | 2B,3B | |
| View All Rankings |
| Charlie Blackmon (COL) | CF | |
| J.D. Martinez (BOS) | RF | |
| Chris Sale (BOS) | SP | |
| Carlos Correa (HOU) | SS | |
| Trea Turner (WSH) | SS | |
| Paul Goldschmidt (ARI) | 1B | |
| Francisco Lindor (CLE) | SS | |
| Giancarlo Stanton (NYY) | RF | |
| Justin Verlander (HOU) | SP | |
| Aaron Judge (NYY) | RF |
| Kris Bryant (CHC) | 3B,RF | |
| Joey Votto (CIN) | 1B | |
| Jacob deGrom (NYM) | SP | |
| George Springer (HOU) | CF,RF | |
| Anthony Rizzo (CHC) | 1B,2B | |
| Luis Severino (NYY) | SP | |
| Gerrit Cole (HOU) | SP | |
| Andrew Benintendi (BOS) | LF,CF | |
| Jose Abreu (CWS) | 1B | |
| Gary Sanchez (NYY) | C |
| Kevin Durant (GSW) | SF,PF | |
| Giannis Antetokounmpo (MIL) | SF,PF | |
| James Harden (HOU) | PG,SG | |
| Stephen Curry (GSW) | PG,SG | |
| Russell Westbrook (OKC) | PG | |
| Karl-Anthony Towns (MIN) | C | |
| Anthony Davis (NOR) | PF,C | |
| Kawhi Leonard (SAS) | SG,SF | |
| LeBron James (CLE) | SF,PF | |
| Nikola Jokic (DEN) | PF,C | |
| View All Rankings |
| John Wall (WAS) | PG | |
| DeMarcus Cousins (NOR) | PF,C | |
| Chris Paul (HOU) | PG | |
| Damian Lillard (POR) | PG | |
| Jimmy Butler (MIN) | SG,SF | |
| Rudy Gobert (UTH) | C | |
| Kyrie Irving (BOS) | PG,SG | |
| Hassan Whiteside (MIA) | C,PF | |
| Myles Turner (IND) | PF,C | |
| Paul George (OKC) | SG,SF |
| Kyle Lowry (TOR) | PG | |
| Draymond Green (GSW) | SF,PF | |
| Kristaps Porzingis (NYK) | PF,C | |
| Kemba Walker (CHA) | PG | |
| CJ McCollum (POR) | PG,SG | |
| Mike Conley (MEM) | PG | |
| Bradley Beal (WAS) | SG | |
| Klay Thompson (GSW) | SG,SF | |
| Marc Gasol (MEM) | C | |
| Gordon Hayward (BOS) | SG,SF |
