| San Francisco 49ers at Los Angeles Rams | Thursday, October 2nd, 2025 at 8:15pm ET |
Bye Week: ATL, CHI, GB, PIT |
| Minnesota Vikings at Cleveland Browns | Sunday, October 5th, 2025 at 9:30am ET | |
| Denver Broncos at Philadelphia Eagles | Sunday, October 5th, 2025 at 1:00pm ET | |
| Dallas Cowboys at New York Jets | Sunday, October 5th, 2025 at 1:00pm ET | |
| Las Vegas Raiders at Indianapolis Colts | Sunday, October 5th, 2025 at 1:00pm ET | |
| Miami Dolphins at Carolina Panthers | Sunday, October 5th, 2025 at 1:00pm ET | |
| New York Giants at New Orleans Saints | Sunday, October 5th, 2025 at 1:00pm ET | |
| Houston Texans at Baltimore Ravens | Sunday, October 5th, 2025 at 1:00pm ET | |
| Tampa Bay Buccaneers at Seattle Seahawks | Sunday, October 5th, 2025 at 4:05pm ET | |
| Tennessee Titans at Arizona Cardinals | Sunday, October 5th, 2025 at 4:05pm ET | |
| Washington Commanders at Los Angeles Chargers | Sunday, October 5th, 2025 at 4:25pm ET | |
| Detroit Lions at Cincinnati Bengals | Sunday, October 5th, 2025 at 4:25pm ET | |
| New England Patriots at Buffalo Bills | Sunday, October 5th, 2025 at 8:20pm ET | |
| Kansas City Chiefs at Jacksonville Jaguars | Monday, October 6th, 2025 at 8:15pm ET |
See the Full Season Schedule
