| Green Bay Packers at Arizona Cardinals | Thursday, October 28th, 2021 at 8:20pm ET |
Bye Week: BAL, LV |
| Tennessee Titans at Indianapolis Colts | Sunday, October 31st, 2021 at 1:00pm ET | |
| Los Angeles Rams at Houston Texans | Sunday, October 31st, 2021 at 1:00pm ET | |
| Cincinnati Bengals at New York Jets | Sunday, October 31st, 2021 at 1:00pm ET | |
| Miami Dolphins at Buffalo Bills | Sunday, October 31st, 2021 at 1:00pm ET | |
| Pittsburgh Steelers at Cleveland Browns | Sunday, October 31st, 2021 at 1:00pm ET | |
| Philadelphia Eagles at Detroit Lions | Sunday, October 31st, 2021 at 1:00pm ET | |
| San Francisco 49ers at Chicago Bears | Sunday, October 31st, 2021 at 1:00pm ET | |
| Carolina Panthers at Atlanta Falcons | Sunday, October 31st, 2021 at 1:00pm ET | |
| Jacksonville Jaguars at Seattle Seahawks | Sunday, October 31st, 2021 at 4:05pm ET | |
| New England Patriots at Los Angeles Chargers | Sunday, October 31st, 2021 at 4:05pm ET | |
| Tampa Bay Buccaneers at New Orleans Saints | Sunday, October 31st, 2021 at 4:25pm ET | |
| Washington Football Team at Denver Broncos | Sunday, October 31st, 2021 at 4:25pm ET | |
| Dallas Cowboys at Minnesota Vikings | Sunday, October 31st, 2021 at 8:20pm ET | |
| New York Giants at Kansas City Chiefs | Monday, November 1st, 2021 at 8:15pm ET |
See the Full Season Schedule
