| New York Jets at Indianapolis Colts | Thursday, November 4th, 2021 at 8:20pm ET |
Bye Week: DET, SEA, TB, WAS |
| Denver Broncos at Dallas Cowboys | Sunday, November 7th, 2021 at 1:00pm ET | |
| Houston Texans at Miami Dolphins | Sunday, November 7th, 2021 at 1:00pm ET | |
| Buffalo Bills at Jacksonville Jaguars | Sunday, November 7th, 2021 at 1:00pm ET | |
| Cleveland Browns at Cincinnati Bengals | Sunday, November 7th, 2021 at 1:00pm ET | |
| Minnesota Vikings at Baltimore Ravens | Sunday, November 7th, 2021 at 1:00pm ET | |
| New England Patriots at Carolina Panthers | Sunday, November 7th, 2021 at 1:00pm ET | |
| Atlanta Falcons at New Orleans Saints | Sunday, November 7th, 2021 at 1:00pm ET | |
| Las Vegas Raiders at New York Giants | Sunday, November 7th, 2021 at 1:00pm ET | |
| Los Angeles Chargers at Philadelphia Eagles | Sunday, November 7th, 2021 at 4:05pm ET | |
| Arizona Cardinals at San Francisco 49ers | Sunday, November 7th, 2021 at 4:25pm ET | |
| Green Bay Packers at Kansas City Chiefs | Sunday, November 7th, 2021 at 4:25pm ET | |
| Tennessee Titans at Los Angeles Rams | Sunday, November 7th, 2021 at 8:20pm ET | |
| Chicago Bears at Pittsburgh Steelers | Monday, November 8th, 2021 at 8:15pm ET |
See the Full Season Schedule
