San Francisco 49ers

The 49ers D/ST allowed 35 points while failing to record any sacks or force any turnovers in a 35-10 loss to the Bills in Week 13.

Fantasy Impact: San Francisco's defense struggled to stop the Bills on a cold, snowy evening in Buffalo. They allowed the Bills to roll up 372 yards of total offense in the blowout loss. San Francisco should have an easier time at home in Week 14 against the Bears.

Jake Moody made one of his three field goals and added an extra point in a 35-10 loss to the Bills in Week 13.

Fantasy Impact: Moody struggled with his accuracy on a snowy, cold night in Buffalo. His lone make came form 33 yards out while he misfired on attempts from 45 and 55 yards out. Moody has now hit 19 of his 25 field-goal attempts this season. He will kick at home against the Bears in Week 14.

George Kittle caught one of his two passes for seven yards in a 35-10 loss to the Bills in Week 13.

Fantasy Impact: Kittle was quiet on a cold, snowy evening in Buffalo. He only registered one catch while dropping his other target. That being said, the 49ers only completed 11 passes with the weather not ideal for passing plays. Despite the slow performance, Kittle remains a solid TE1 in fantasy heading into Week 14 against the Bears.

Ricky Pearsall was unable to catch his lone target in a 35-10 loss to the Bills in Week 13.

Fantasy Impact: Pearsall was quiet on a cold, snowy evening in Buffalo where the 49ers only completed 11 passes. The rookie receiver has failed to record a catch in three consecutive games. He will look to bounce back at home against the Bears in Week 14.

Jauan Jennings caught three of his five targets for 56 yards in a 35-10 loss to the Bills in Week 13.

Fantasy Impact: Jennings led the 49ers in receiving on a cold, snowy evening in Buffalo that suppressed the passing game for both teams. The veteran wideout has been excellent for the 49ers since the Brandon Aiyuk (knee) injury and remains a quality fantasy starter moving forward. He will face the Bears at home in Week 14.

Deebo Samuel Sr. caught four of his five targets for 20 yards while losing a fumble in a 35-10 loss to the Bills in Week 13.

Fantasy Impact: Samuel turned in yet another pedestrian outing on a cold, snowy evening in Buffalo. The veteran wideout has just nine catches for 63 yards over his past three games and hasn't scored a touchdown since October 10 against Seattle. He is tough to trust in fantasy until he starts to show signs of life. The 49ers will face off against the Bears in Week 14.

Isaac Guerendo carried the ball four times for 19 yards and a touchdown while losing three yards on his lone reception in a 35-10 loss to the Bills in Week 13.

Fantasy Impact: Guerendo found the end zone on a 15-yard run in the third quarter for the 49ers' lone touchdown. He saw some extra work with the 49ers losing Christian McCaffrey to what is feared to be a season-ending PCL injury in the first half. If that is the case, Guerendo will assume the backup role to Jordan Mason moving forward, making him a valuable handcuff in fantasy. He is worth a waiver claim in deeper leagues this week as San Francisco begins preparing to face the Bears in Week 14.

Jordan Mason carried the ball 13 times for 78 yards in a 35-10 loss to the Bills in Week 13.

Fantasy Impact: Starting running back Christian McCaffrey suffered what may be a season-ending PCL injury in his knee and left before halftime, which pushed Mason back into the lead role, a role in which he thrived in the first half of the season. The veteran responded well on a cold, snowy evening in Buffalo, posting his best yardage game since October 6 against Arizona. With Mason looking like the 49ers' starting running back for the rest of the season, fantasy managers will want to check waiver wires this week to see if he is out there. The 49ers face the Bears in Week 14.

Brock Purdy completed 11 of his 18 passes for 94 yards and added two rushes for four yards and a lost fumble in a 35-10 loss to the Bills in Week 13.

Fantasy Impact: Purdy made his return to the field after missing Week 12 with a shoulder injury but the conditions were less than ideal for the passing game on a cold and snowy evening in Buffalo. He also lost star running back Christian McCaffrey to a potential season-ending PCL injury in the contest. Purdy now has thrown 13 touchdowns and eight interceptions on the season. A rest-of-season QB2 thanks to the 49ers' recent struggles on offense, he will look to bounce back in Week 14's home matchup against the Bears.

The 49ers have ruled out Christian McCaffrey for the remainder of Sunday's game against the Bills. (Source: San Francisco 49ers on Twitter)

Fantasy Impact: McCaffrey had gone down by himself before heading to the locker room. It was reportedly a contact injury from the play prior. There should be further updates on his status early this upcoming week. Jordan Mason and Isaac Guerendo will handle the carries for the rest of the game.

Nick Bosa (hip/oblique) has been ruled out for Week 13 for the San Francisco 49ers against the Buffalo Bills. (Source: Tom Pelissero on Twitter)

Fantasy Impact: Bosa will miss a second consecutive contest, leaving the San Francisco defense without its top pass-rushing option against Buffalo quarterback Josh Allen and the Bills Sunday night.

Trent Williams (ankle) has been ruled out for Week 13 for the San Francisco 49ers against the Buffalo Bills. (Source: Tom Pelissero on Twitter)

Fantasy Impact: Williams will remain sidelined for San Francisco, leaving the starting offensive line without its top player against the Bills Sunday night.

Brandon Allen completed 17-of-29 passing attempts for 199 yards, one touchdown, and one interception and had a lost fumble in Sunday's 38-10 loss to the Green Bay Packers.

Fantasy Impact: Allen got the start for the 49ers with Brock Purdy (shoulder) out of the lineup, but he didn't have a very good game. He committed two turnovers on the day and wasn't able to lead San Francisco's offense to more than ten points against Green Bay, which led to them suffering a blowout loss. The 49ers' skill-position players will continue to struggle for however long Purdy remains out of the lineup moving forward.

Eric Saubert caught his lone target for seven yards in the 49ers 20-17 loss against the Seahawks.

Fantasy Impact: Saubert saw some more snaps with George Kittle sidelined. He remains off the fantasy radar.

49ers GM John Lynch said "we're getting closer" to having Dre Greenlaw coming back. (Source: Matt Barrows on Twitter)

Fantasy Impact: Lynch added that once Greenlaw's practice window opens, he will use a good chunk of that window. He is likely still at least a few weeks away from officially returning for San Francisco.

Yetur Gross-Matos is on track to return on Sunday against the Seahawks. (Source: David Lombardi on Twitter)

Fantasy Impact: It's "looking pretty good" according to 49ers GM John Lynch. Gross-Matos has been sidelined for the past month after undergoing surgery on his knee.

The 49ers signed Pat O'Donnell to their practice squad.

Fantasy Impact: San Francisco punter Mitch Wishnowsky suffered a back injury last week. If he can't go on Sunday, O'Donnell will be activated to start.

The 49ers signed LB Jalen Graham to their practice squad. (Source: San Francisco 49ers on Twitter)

Fantasy Impact: Graham will add depth to the linebacker room for San Francisco. The 49ers released OL Dieter Eiselen from the practice squad as the corresponding move.

Anders Carlson made all three of his field goals while adding three extra points in a 30-24 win over Dallas in Week 8.

Fantasy Impact: Carlson was perfect on the evening, making field goals from 50, 44, and 41 yards out. The veteran kicker has done an admirable job filling in for the injured Jake Moody (ankle) over the past two games, going 5-for-5 on field goals. The 49ers will be on bye in Week 9, giving Moody an extra week to get healthy.

George Odum has been listed as questionable for Sunday's game against the Cowboys. (Source: Josh Dubow on Twitter)

Fantasy Impact: Odum was limited at practice on Thursday and Friday. He should be on the favorable side of questionable heading into Sunday.