San Francisco 49ers

Deebo Samuel (groin) did not practice on Wednesday. But the thought is that he should be good to go for Week 14 as of right now. (Source: Pro Football Talk on Twitter)

Fantasy Impact: Groin injuries can be tricky and tend to linger so this is certainly a situation to monitor as the week progresses.

49ers RB Elijah Mitchell (concussion, knee) didn't practice on Wednesday. (Source: David Lombardi on Twitter)

Fantasy Impact: Mitchell is dealing with "knee irritation" in addition to be in the league's concussion protocol. The 49ers signed Brian Hill, which likely means they need a fill-in RB for Week 14. JaMycal Hasty should be rostered everywhere while we wait for this situation to play out.

San Francisco 49ers running back Jeff Wilson Jr. had a "flare-up" on his surgically repaired knee during Sunday's loss to the Seahawks, per Matt Maiocco of NBC Sports Bay Area. (Source: Matt Maiocco on Twitter)

Fantasy Impact: Head coach Kyle Shanahan told reporters that it has happened before and that it usually bothers Wilson Jr. for a few days before he can get right. This partially explains why Wilson Jr. was a no-show during Sunday's loss against the Seahawks and it makes him questionable heading into next Sunday's game against the Bengals. Starting running back Elijah Mitchell (head) is also in the concussion protocol, which leaves JaMycal Hasty as the only healthy running back on the roster for now.

San Francisco 49ers wide receiver Brandon Aiyuk hauled in 3-of-6 targets for 55 scoreless yards in Sunday's 30-23 loss to the Seattle Seahawks.

Fantasy Impact: It was a slow game for Aiyuk on Sunday as George Kittle (9-181-2) dominated the target share. The second-year wideout didn't even record a catch in the first half of the game but picked up a few chunk plays in the third and fourth quarters. He had a few drops as well, which hurt the 49ers' chances to keep pace with the Seahawks' offense. He was still second on the team in targets and catches and should perform better next week when the Niners take on the Bengals in Cincinnati.

San Francisco 49ers quarterback Jimmy Garoppolo completed 20-of-30 passes for 299 yards, two touchdowns, and two interceptions in a 30-23 loss to the Seahawks on Sunday.

Fantasy Impact: Garoppolo and the Niners struggled more than the box score would indicate on Sunday. Both of his touchdown throws went to George Kittle, who made some impressive individual efforts on both grabs. He also threw a pair of untimely interceptions in the second and third quarters as the Niners attempted to get their drives going in the back-and-forth contest. Despite his struggles, he was able to march San Francisco all the way down to the Seattle four-yard line with a chance to tie the ball game inside of 30 seconds. Unfortunately, his fourth-down pass was tipped by Carlos Dunlap, and San Francisco was swept by the hapless Seahawks this season. The Niners and "Jimmy G" will look to regroup next week when they visit Cincinnati to face the Bengals.

San Francisco 49ers tight end George Kittle hauled in 9-of-12 targets for 181 yards and two touchdowns in a 30-23 loss to the Seahawks on Sunday.

Fantasy Impact: Deebo Samuel sat this game out with a groin injury so Kittle was able to notch a season-high 12 targets. He made good use of those targets with nine grabs, 181 yards, and two scores, which were all season highs as well. He showed off his athleticism with nifty scoring grabs of 24 and 48 yards. Kittle is a locked-in TE1 next week when the Niners head to Cincinnati to battle the Bengals.

The 49ers placed RB Trey Sermon (ankle) on injured reserve. (Source: Nick Wagoner on Twitter)

Fantasy Impact: Sermon was carted off the field last week and this injury will now sideline him for at least three games. It has been a brutal rookie campaign for the third-round RB. Elijah Mitchell should once again operate as San Francisco's workhorse.

49ers RB JaMycal Hasty (ankle) practiced again on Thursday. (Source: Matt Barrows on Twitter)

Fantasy Impact: However, Elijah Mitchell remains the workhorse in this backfield. Hasty isn't on the fantasy radar ahead of a Week 13 matchup against the Seahawks.

The Atletic expects Jauan Jennings to become the No. 2 wide receiver for the San Francisco 49ers following the injury to Deebo Samuel. (Source: The Athletic)

Fantasy Impact: Samuel is expected to miss one-to-two weeks after suffering an injury Week 12. His absence would push Brandon Aiyuk into the No. 1 WR role, and The Athletic expects Jennings to move into the No. 2 role. Jennings saw three targets against the Vikings Week 12, finishing with two catches for 24 yards and a touchdown. While he may not see a ton of volume, he does seem to be a red-zone target given his large frame. He'll be the third option, also including George Kittle, on a team that prefers to run the ball, but he's someone that's worth keeping an eye on should Samuel miss more time than expected.

Fred Warner is expected to miss Week 13 with a hamstring strain. (Source: Nick Wagoner via Twitter)

Fantasy Impact: Warner has been good for IDP fantasy managers this season and will be missed. This also means the Niners' defense as a unit should not be started against the Seahawks.

The San Francisco 49ers' defense held the Jacksonville Jaguars to 10 points while recording three sacks and a pair of fumble recoveries in a Week 11 win.

Fantasy Impact: The Niners were in firm control from the outset in this one. The Jags scored just three points in the first half and didn't find the end zone until the end of the fourth quarter after the game was well in hand. They weren't able to intercept rookie quarterback Trevor Lawrence but they did sack him three times and forced a pair of fumbles. The Niners defensive unit will have their work cut out for them next week when they host the Vikings.

San Francisco 49ers cornerback Josh Norman is active for Monday Night Football against the Los Angeles Rams. (Source: Matt Maiocco on Twitter)

Fantasy Impact: Norman was limited in practice all week with the rib injury but will suit up for what should be an exciting matchup against a divisional opponent. While no longer the highly regarded number one he once was, Norman is still a key part of the 49ers secondary. He has been targeted less in coverage this season but has still found a way to get it done for IDP managers in CB leagues, recording back-to-back games of seven solo tackles in Week 7 and Week 8. He is more CB3 than CB2 for Week 10 due to an uncertain workload.

The San Francisco 49ers placed defensive lineman Dee Ford (back) on the injured reserve Saturday. (Source: Cam Inman on Twitter)

Fantasy Impact: Ford has been dealing with a back injury and was questionable heading into Sunday's game against the Arizona Cardinals. The 30-year-old needs additional time to recover from his back issue and will miss at least the next three weeks. Ford racked up five tackles, three sacks, and a forced fumble over six games in 2021. Jordan Willis should see an uptick in snaps while Ford is sidelined.

The 49ers activated Robbie Gould off injured reserve on Saturday. (Source: Matt Maiocco on Twitter)

Fantasy Impact: This was a foregone conclusion after the 49ers released Joey Slye earlier in the week. Gould had hit 3 of 4 field-goal attempts and all 11 of his extra-point attempts this season, and should go back to being a borderline startable option generally and in Week 9 against the Cardinals.

Trent Williams (ankle) will continue to be monitored by the training staff this week after he made his return in week 8. (Source: Nick Wagoner via Twitter)

Fantasy Impact: Williams had an up and down start to the game but looked good as he settled against an aggressive Bears front. Williams' presence is going to be needed against another strong pass rushing squad in the Cardinals.

49ers QB Trey Lance (knee) has been removed from the team's Week 8 injury report. (Source: Nick Wagoner on Twitter)

Fantasy Impact: Lance should be good to go as Jimmy Garoppolo's back on Sunday against the Bears. He's worth stashing in deeper single-QB leagues as well as two-QB/SuperFlex formats.

San Francisco 49ers tight end Ross Dwelley caught his only target for a 21-yard touchdown in Sunday's Week 4 loss to the Seattle Seahawks.

Fantasy Impact: Dwelley caught a 21-yard touchdown strike from Jimmy Garoppolo early in the first quarter on Sunday. It was his only catch (and target) of the ball game. It was also the backup tight end's first catch of the season. It was a bit of a flukey score so don't expect Dwelley to repeat next week against the Cardinals.

Newly signed CB Dre Kirkpatrick is listed as inactive for Sunday night's game versus Green Bay. (Source: San Francisco 49ers on Twitter)

Fantasy Impact: Kirkpatrick was brought in to replace Jason Verrett, who was lost for the season with a torn ACL. He may be available for next week's contest against the Seahawks.

Kerryon Johnson was elevated the 49ers active roster ahead of Sunday's game against the Packers. (Source: Adam Schefter on Twitter )

Fantasy Impact: Trey Sermon was cleared from concussion protocol and should get the start with Elijah Mitchell (shoulder) doubtful. Johnson, Trenton Cannon and the newly signed Jaques Patrick are the healthy running backs for San Francisco alongside Sermon.

The 49ers signed RB Chris Thompson to their practice squad. (Source: Adam Schefter on Twitter)

Fantasy Impact: San Francisco's RB room is pretty banged up entering Week 3, so it makes sense to bring in more healthy bodies. Thompson is very unlikely to have fantasy value this season.